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The clinical study for TMS-19-Q.O tablet was performed with multicenter trial. The results obtained were as follows; Final global improvement rating in 332 cases of otorhinolaryngological infections were excellent in 99, good in 142, fair in 40 and poor in 51 and the effective rate was 72.6%. Those of 266 cases with acute infection were excellent in 93 and good in 121 and the effective rate was 80.5%. Optimum daily doses would be 600 mg based on the analysis of 144 cases of the acute infection with sensitive bacteria (MIC: less than or equal to 3.13 micrograms/ml). In acute infection, major causative bacteria were Gram-positive cocci (GPC) indicating the frequency of 72.0% in total isolates and 87.5% in singly isolated cases. In chronic infection, although GPC were also dominant, Gram-negative bacilli were observed in 31.9%. Clinical and bacteriological effective rates of 160 cases of acute infection with single species were 80.6% and 90.3%, and those of 43 cases in chronic infection were 44.2% and 72.7%, respectively. The resistant rates of isolates in acute infection to TMS-19-Q were 13.3% in S. aureus, 7.7% in S. epidermidis, 6.0% in S. pyogenes and 0% in S. pneumoniae. Those in chronic infection were 20.0% in S. aureus and 25.0% in S. epidermidis. Slight adverse reactions, such as skin eruption or gastrointestinal disorders were observed in 14 cases and no severe one was observed. Slight elevation of GOT, GPT, Al-P, BUN, S-Cr. or eosinophil were observed in 12 cases. These results suggest that TMS-19-Q would be useful antibiotic for otorhinolaryngological infections.
S Baba, and
K Wada, and
T Hatano, and
K Murai, and
H Kinoshita, and
S Kawamura, and
R Sugita, and
Y Fujimaki, and
B Sanbe, and
R Ueda
March 1985,
The Japanese journal of antibiotics,
S Baba, and
K Wada, and
T Hatano, and
K Murai, and
H Kinoshita, and
S Kawamura, and
R Sugita, and
Y Fujimaki, and
B Sanbe, and
R Ueda
February 1989,
The Japanese journal of antibiotics,
S Baba, and
K Wada, and
T Hatano, and
K Murai, and
H Kinoshita, and
S Kawamura, and
R Sugita, and
Y Fujimaki, and
B Sanbe, and
R Ueda
March 1997,
The Japanese journal of antibiotics,
S Baba, and
K Wada, and
T Hatano, and
K Murai, and
H Kinoshita, and
S Kawamura, and
R Sugita, and
Y Fujimaki, and
B Sanbe, and
R Ueda
November 1967,
Semaine therapeutique,
S Baba, and
K Wada, and
T Hatano, and
K Murai, and
H Kinoshita, and
S Kawamura, and
R Sugita, and
Y Fujimaki, and
B Sanbe, and
R Ueda
January 1994,
The Japanese journal of antibiotics,
S Baba, and
K Wada, and
T Hatano, and
K Murai, and
H Kinoshita, and
S Kawamura, and
R Sugita, and
Y Fujimaki, and
B Sanbe, and
R Ueda
June 2000,
The Japanese journal of antibiotics,
S Baba, and
K Wada, and
T Hatano, and
K Murai, and
H Kinoshita, and
S Kawamura, and
R Sugita, and
Y Fujimaki, and
B Sanbe, and
R Ueda
January 1988,
Plucne bolesti : casopis Udruzenja pneumoftiziologa Jugoslavije = the journal of Yugoslav Association of Phthisiology and Pneumology,
S Baba, and
K Wada, and
T Hatano, and
K Murai, and
H Kinoshita, and
S Kawamura, and
R Sugita, and
Y Fujimaki, and
B Sanbe, and
R Ueda
January 1967,
Revista clinica espanola,
S Baba, and
K Wada, and
T Hatano, and
K Murai, and
H Kinoshita, and
S Kawamura, and
R Sugita, and
Y Fujimaki, and
B Sanbe, and
R Ueda
March 1985,
The Japanese journal of antibiotics,
S Baba, and
K Wada, and
T Hatano, and
K Murai, and
H Kinoshita, and
S Kawamura, and
R Sugita, and
Y Fujimaki, and
B Sanbe, and
R Ueda
February 1989,
The Japanese journal of antibiotics,
