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Twenty-one patients with chronic granulocytic leukaemia underwent marrow transplantation. The donors were human-lymphocyte antigen-identical siblings in 19 cases. In the remaining 2 cases the donor was a parent in one and an identical twin in the other. The preparatory regimen included cyclophosphamide and 8.6 Gy total body irradiation given at either a dose of 0.1 Gy/min or 0.04 Gy/min. Five patients were in the accelerated phase of the disease, one was in remission following blast crisis, and the rest were all in the chronic phase. After chemotherapy and irradiation, all patients received bone marrow transplants. To date, nine patients are still alive, with a median survival of 64 days (range 28-683 days). One patient continued to have leukaemic cells and in another, the leukaemia recurred 18 months following transplantation. Interstitial pneumonitis was the cause of death of eight patients (38%). Graft-versus-host disease occurred in ten patients (47%).
H K Mahmoud, and
U W Schaefer, and
F Schüning, and
D Beelen, and
R Becher, and
C G Schmidt, and
W Alberti, and
E Haralambie, and
G Linzenmeier, and
B Stollmann
October 1983,
Clinics in haematology,
H K Mahmoud, and
U W Schaefer, and
F Schüning, and
D Beelen, and
R Becher, and
C G Schmidt, and
W Alberti, and
E Haralambie, and
G Linzenmeier, and
B Stollmann
June 1983,
Lancet (London, England),
H K Mahmoud, and
U W Schaefer, and
F Schüning, and
D Beelen, and
R Becher, and
C G Schmidt, and
W Alberti, and
E Haralambie, and
G Linzenmeier, and
B Stollmann
January 1986,
Lancet (London, England),
H K Mahmoud, and
U W Schaefer, and
F Schüning, and
D Beelen, and
R Becher, and
C G Schmidt, and
W Alberti, and
E Haralambie, and
G Linzenmeier, and
B Stollmann
January 1987,
Haematologica,
H K Mahmoud, and
U W Schaefer, and
F Schüning, and
D Beelen, and
R Becher, and
C G Schmidt, and
W Alberti, and
E Haralambie, and
G Linzenmeier, and
B Stollmann
June 1986,
Journal of the National Cancer Institute,
H K Mahmoud, and
U W Schaefer, and
F Schüning, and
D Beelen, and
R Becher, and
C G Schmidt, and
W Alberti, and
E Haralambie, and
G Linzenmeier, and
B Stollmann
November 1986,
Cancer,
H K Mahmoud, and
U W Schaefer, and
F Schüning, and
D Beelen, and
R Becher, and
C G Schmidt, and
W Alberti, and
E Haralambie, and
G Linzenmeier, and
B Stollmann
October 1982,
British journal of haematology,
H K Mahmoud, and
U W Schaefer, and
F Schüning, and
D Beelen, and
R Becher, and
C G Schmidt, and
W Alberti, and
E Haralambie, and
G Linzenmeier, and
B Stollmann
November 1987,
British journal of haematology,
H K Mahmoud, and
U W Schaefer, and
F Schüning, and
D Beelen, and
R Becher, and
C G Schmidt, and
W Alberti, and
E Haralambie, and
G Linzenmeier, and
B Stollmann
November 1981,
Experimental hematology,
H K Mahmoud, and
U W Schaefer, and
F Schüning, and
D Beelen, and
R Becher, and
C G Schmidt, and
W Alberti, and
E Haralambie, and
G Linzenmeier, and
B Stollmann
April 1987,
Bone marrow transplantation,
