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In a cross-over double-blind trial on 15 healthy male volunteers the effect on physical exercise capacity and metabolism of single oral doses of 90 mg diltiazem or 20 mg nifedipine was compared. Both maximal physical exercise capacity and sustained exercise capacity remained unchanged after each calcium antagonist. Heart rate was higher after nifedipine but lower after diltiazem than after placebo, although the differences at the individual exercise steps were small and significant in only some. Plasma noradrenaline levels on submaximal exercise rose significantly higher after nifedipine than after diltiazem or placebo. Somatotropin, cortisol, insulin as well as carbohydrate and fat metabolic substrates were similar after the two calcium antagonists and placebo. It is concluded that short-term administration of diltiazem and nifedipine does not influence physical exercise capacity and metabolism.
W Kindermann, and
W Schmitt, and
E Stengele
January 1992,
Klinicheskaia meditsina,
W Kindermann, and
W Schmitt, and
E Stengele
March 1981,
Biochemical pharmacology,
W Kindermann, and
W Schmitt, and
E Stengele
October 1971,
The New England journal of medicine,
W Kindermann, and
W Schmitt, and
E Stengele
January 1990,
Hormone and metabolic research. Supplement series,
W Kindermann, and
W Schmitt, and
E Stengele
January 1978,
Bollettino della Societa italiana di cardiologia,
W Kindermann, and
W Schmitt, and
E Stengele
January 1993,
Eksperimental'naia i klinicheskaia farmakologiia,
W Kindermann, and
W Schmitt, and
E Stengele
April 1992,
Kardiologiia,
W Kindermann, and
W Schmitt, and
E Stengele
February 1990,
The Physiologist,
W Kindermann, and
W Schmitt, and
E Stengele
August 1990,
Medical hypotheses,
W Kindermann, and
W Schmitt, and
E Stengele
January 1989,
Acta pharmaceutica Hungarica,
