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Blood glucose, plasma GH, insulin and glucagon levels during OGTT before and after treatment with bromocriptine (20 - 40 mg daily 3 - 18 months) were studied in 12 nondiabetic acromegalics (NA) and 6 diabetic acromegalics (DA) not treated previously. There was no significant change in blood glucose levels before and after treatment in NA while blood glucose levels fell significantly in DA after treatment. Mean basal GH levels and after OGTT decreased significantly in NA group, while only in the 120 min of OGTT in DA group. There was no significant change in mean basal or glucose stimulated plasma insulin or glucagon levels before and after treatment in both non-diabetic and diabetic acromegalics. Normal glucagon levels in diabetic acromegalics prior to treatment is considered as relative hyperglucagonaemia which disappeared after treatment. We did not show that glucagon suppressibility after OGTT was reestablished after treatment with bromocriptine in non-diabetic and diabetic acromegalics. Other factors than changes in hormones should be considered as a cause of restored glucose tolerance.
V Popović, and
D Micić, and
M Nesović, and
P Djordjević, and
J Mićić, and
D S Djurić
February 1982,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
V Popović, and
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M Nesović, and
P Djordjević, and
J Mićić, and
D S Djurić
February 1975,
British medical journal,
V Popović, and
D Micić, and
M Nesović, and
P Djordjević, and
J Mićić, and
D S Djurić
May 1977,
Metabolism: clinical and experimental,
V Popović, and
D Micić, and
M Nesović, and
P Djordjević, and
J Mićić, and
D S Djurić
June 1979,
Australian and New Zealand journal of medicine,
V Popović, and
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M Nesović, and
P Djordjević, and
J Mićić, and
D S Djurić
November 1978,
The Medical journal of Australia,
V Popović, and
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M Nesović, and
P Djordjević, and
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D S Djurić
May 1979,
Drugs,
V Popović, and
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M Nesović, and
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D S Djurić
May 1993,
The Clinical investigator,
V Popović, and
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M Nesović, and
P Djordjević, and
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D S Djurić
November 2001,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
V Popović, and
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M Nesović, and
P Djordjević, and
J Mićić, and
D S Djurić
October 1981,
The New England journal of medicine,
V Popović, and
D Micić, and
M Nesović, and
P Djordjević, and
J Mićić, and
D S Djurić
February 1986,
Clinical endocrinology,
