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The in vitro plasma protein binding was determined in nine maintenance hemodialysis patients who later underwent renal transplantation. The organic acid fluorescein (10 micrograms/ml) or the organic base quinidine (5 micrograms/ml) was added to the pre and post transplant serum of these patients. Drug concentrations were measured spectrophotofluorometrically after equilibrium dialysis. The results were compared with the plasma protein binding of eight normal volunteers. The patients on maintenance hemodialysis had lower plasma protein binding of fluorescein than normals (78 +/- 5% vs 89 +/- 4, p less than 0.001). Plasma protein binding improved significantly after renal transplantation (85 +/- 3, p less than 0.01) but was still lower than in normals (p 0.05). Plasma protein binding of quinidine was not significantly different than in normal volunteers (77 +/- 8%) either prior to (72 +/- 10%) or after (73 +/- 12%) kidney transplantation. Plasma protein binding of quinidine remains unaffected by renal transplantation. However, the abnormal plasma protein binding or organic acids in chronic renal failure may be significantly improved by renal transplantation.
M B Affrime, and
D L Blecker, and
P J Lyons, and
J M Pitone, and
C D Swartz, and
D T Lowenthal
April 1980,
Journal of pharmaceutical sciences,
M B Affrime, and
D L Blecker, and
P J Lyons, and
J M Pitone, and
C D Swartz, and
D T Lowenthal
January 1977,
Clinical pharmacokinetics,
M B Affrime, and
D L Blecker, and
P J Lyons, and
J M Pitone, and
C D Swartz, and
D T Lowenthal
January 1988,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
M B Affrime, and
D L Blecker, and
P J Lyons, and
J M Pitone, and
C D Swartz, and
D T Lowenthal
October 1976,
Journal of clinical pharmacology,
M B Affrime, and
D L Blecker, and
P J Lyons, and
J M Pitone, and
C D Swartz, and
D T Lowenthal
November 1976,
Clinical pharmacology and therapeutics,
M B Affrime, and
D L Blecker, and
P J Lyons, and
J M Pitone, and
C D Swartz, and
D T Lowenthal
February 1982,
The Journal of pharmacy and pharmacology,
M B Affrime, and
D L Blecker, and
P J Lyons, and
J M Pitone, and
C D Swartz, and
D T Lowenthal
January 1984,
Journal of clinical pharmacology,
M B Affrime, and
D L Blecker, and
P J Lyons, and
J M Pitone, and
C D Swartz, and
D T Lowenthal
August 1975,
Journal of pharmaceutical sciences,
M B Affrime, and
D L Blecker, and
P J Lyons, and
J M Pitone, and
C D Swartz, and
D T Lowenthal
July 1999,
Journal of clinical pharmacology,
M B Affrime, and
D L Blecker, and
P J Lyons, and
J M Pitone, and
C D Swartz, and
D T Lowenthal
November 2013,
Bioanalysis,
