-transparent.png){kind=logo}
Overlapping recombinant clones that encompass the insulin-like growth factor (IGF) I and II genes have been isolated from a human genomic DNA library. Each gene is present once per haploid genome; the IGF-I gene spans greater than 35 kilobase pairs (kbp) and the IGF-II gene is at least 15 kbp. The exon-intron organization of these genes is similar, each having four exons, which is one more than the related insulin gene. Comparison of the restriction endonuclease cleavage maps of the IGF-II and insulin genes, including their flanking regions and hybridization with an IGF-II cDNA probe, revealed that they are adjacent to one another. The IGF-II and insulin genes have the same polarity and are separated by 12.6 kbp of intergenic DNA that includes a dispersed middle repetitive Alu sequence. The order of the genes is 5'-insulin-IGF-II-3'.
G I Bell, and
D S Gerhard, and
N M Fong, and
R Sanchez-Pescador, and
L B Rall
March 1988,
Biochemical and biophysical research communications,
G I Bell, and
D S Gerhard, and
N M Fong, and
R Sanchez-Pescador, and
L B Rall
May 1993,
Fertility and sterility,
G I Bell, and
D S Gerhard, and
N M Fong, and
R Sanchez-Pescador, and
L B Rall
April 1994,
DNA and cell biology,
G I Bell, and
D S Gerhard, and
N M Fong, and
R Sanchez-Pescador, and
L B Rall
October 1988,
Neuroscience letters,
G I Bell, and
D S Gerhard, and
N M Fong, and
R Sanchez-Pescador, and
L B Rall
August 1990,
Biochemistry international,
G I Bell, and
D S Gerhard, and
N M Fong, and
R Sanchez-Pescador, and
L B Rall
March 1992,
Growth regulation,
G I Bell, and
D S Gerhard, and
N M Fong, and
R Sanchez-Pescador, and
L B Rall
January 1990,
Acta paediatrica Scandinavica. Supplement,
G I Bell, and
D S Gerhard, and
N M Fong, and
R Sanchez-Pescador, and
L B Rall
January 1984,
Nature,
G I Bell, and
D S Gerhard, and
N M Fong, and
R Sanchez-Pescador, and
L B Rall
March 1992,
Genomics,
G I Bell, and
D S Gerhard, and
N M Fong, and
R Sanchez-Pescador, and
L B Rall
January 2005,
Anticancer research,
