Biomaterial Database

Proteins from Salmonella R-mutants mediating protection against Salmonella typhimurium infection in mice. II. Protection tests performed with proteins free from lipopolysaccharide. 1985

S Schlecht, and N Bhatnagar

Lipopolysaccharide-free proteins obtained from R-mutants of Salmonella typhimurium, S. minnesota and S. dublin as well as those from an S-form of S. typhimurium mediated protection in mice against experimental infection with S. typhimurium. The protection was measured by LD50 and is statistically significant. The level of protection of all the preparations was similar. Non-bacterial proteins had no effect under similar experimental conditions. Protection afforded by the purified proteins was lower than that of the corresponding complex crude extract; supplementation of proteins with lipopolysaccharide and phospholipids in model membrane vesicles enhanced their potency. However, lipopolysaccharides or phospholipids alone were not able to increase the efficacy of purified proteins. Some other fractions obtained by gel filtration of the crude extract also afford protection.

UI	MeSH Term	Description	Entries
D008070	Lipopolysaccharides	Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)	Lipopolysaccharide,Lipoglycans
D009154	Mutation	Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.	Mutations
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001426	Bacterial Proteins	Proteins found in any species of bacterium.	Bacterial Gene Products,Bacterial Gene Proteins,Gene Products, Bacterial,Bacterial Gene Product,Bacterial Gene Protein,Bacterial Protein,Gene Product, Bacterial,Gene Protein, Bacterial,Gene Proteins, Bacterial,Protein, Bacterial,Proteins, Bacterial
D001428	Bacterial Vaccines	Suspensions of attenuated or killed bacteria administered for the prevention or treatment of infectious bacterial disease.	Bacterial Vaccine,Bacterin,Vaccine, Bacterial,Vaccines, Bacterial
D012480	Salmonella Infections	Infections with bacteria of the genus SALMONELLA.	Salmonellosis,Infections, Salmonella,Infection, Salmonella,Salmonella Infection,Salmonelloses
D012486	Salmonella typhimurium	A serotype of Salmonella enterica that is a frequent agent of Salmonella gastroenteritis in humans. It also causes PARATYPHOID FEVER.	Salmonella typhimurium LT2
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus

Related Publications

S Schlecht, and N Bhatnagar

[Experimental protective immunization of mice against S. typhimurium infection by Salmonella R mutants].

January 1974, Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie,

S Schlecht, and N Bhatnagar

The protein-lipopolysaccharide complex extracted with trichloracetic acid from Salmonella typhimurium effective in protection of mice against S. typhimurium infection.

July 1982, Parasite immunology,

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August 1984, Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology,

S Schlecht, and N Bhatnagar

[Immunization against salmonella typhimurium infection in mice. Chemical composition and protecting activity of different extracts from salmonella R mutants (author's transl)].

January 1980, Zentralblatt fur Bakteriologie. 1. Abt. Originale. A: Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie,

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