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Laboratory studies were performed on 3 Collies with familial canine dermatomyositis, 6 progeny from a breeding of 2 of the Collies (incross litter), and 4 progeny from the breeding of an affected Collie male and a normal Labrador Retriever (outcross litter). Hematologic abnormalities were leukogram changes consistent with inflammation, and, in 2 severely affected incross dogs, anemia of inflammatory disease. Serum muscle enzyme activities were not markedly increased. High concentrations of immune complexes and proportionally increased total immunoglobulin G were present in the sera of moderately and severely affected incross dogs. The same dogs had weakly positive direct Coombs' tests, and 1 affected outcross dog had a strongly positive direct Coombs' test. Rheumatoid factor was present in a severely affected incross dog. A few dogs had polyclonal globulin increases that were attributed to inflammation. Low antibody titers to canine calicivirus were present in 3 dogs and a low titer to canine coronavirus was present in 1 dog.
K H Haupt, and
D J Prieur, and
A M Hargis, and
R L Cowell, and
T L McDonald, and
L L Werner, and
J F Evermann
December 1988,
Veterinary immunology and immunopathology,
K H Haupt, and
D J Prieur, and
A M Hargis, and
R L Cowell, and
T L McDonald, and
L L Werner, and
J F Evermann
October 1965,
American journal of diseases of children (1960),
K H Haupt, and
D J Prieur, and
A M Hargis, and
R L Cowell, and
T L McDonald, and
L L Werner, and
J F Evermann
January 1991,
Acta dermato-venereologica,
K H Haupt, and
D J Prieur, and
A M Hargis, and
R L Cowell, and
T L McDonald, and
L L Werner, and
J F Evermann
November 1987,
Journal of the American Veterinary Medical Association,
K H Haupt, and
D J Prieur, and
A M Hargis, and
R L Cowell, and
T L McDonald, and
L L Werner, and
J F Evermann
December 1971,
The American journal of cardiology,
K H Haupt, and
D J Prieur, and
A M Hargis, and
R L Cowell, and
T L McDonald, and
L L Werner, and
J F Evermann
May 1963,
American journal of veterinary research,
K H Haupt, and
D J Prieur, and
A M Hargis, and
R L Cowell, and
T L McDonald, and
L L Werner, and
J F Evermann
April 1973,
American journal of veterinary research,
K H Haupt, and
D J Prieur, and
A M Hargis, and
R L Cowell, and
T L McDonald, and
L L Werner, and
J F Evermann
May 1980,
American journal of veterinary research,
K H Haupt, and
D J Prieur, and
A M Hargis, and
R L Cowell, and
T L McDonald, and
L L Werner, and
J F Evermann
October 1970,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
K H Haupt, and
D J Prieur, and
A M Hargis, and
R L Cowell, and
T L McDonald, and
L L Werner, and
J F Evermann
March 1978,
Arthritis and rheumatism,
