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A controlled randomized trial of plasma exchange combined with prednisone was compared with supportive care alone in patients with Guillain-Barré syndrome (GBS). There was no significant improvement in the treated group over the controls. The sample size, albeit small (12 treated and 13 controls), had the power (95% chance) to detect a change of 2 British Medical Research Council grades of strength between the groups. The difference in our results and others that indicated a beneficial effect of plasma exchange may reflect an adverse effect of prednisone on recovery in GBS. Failure to find a benefit of plasma exchange in our patients also raises the possibility that GBS may be a heterogeneous disorder with humoral factors playing a role in some but not all patients.
J R Mendell, and
J T Kissel, and
M S Kennedy, and
Z Sahenk, and
H T Grinvalsky, and
G L Pittman, and
R S Kyler, and
R I Roelofs, and
J N Whitaker, and
T E Bertorini
December 1994,
Transfusion science,
J R Mendell, and
J T Kissel, and
M S Kennedy, and
Z Sahenk, and
H T Grinvalsky, and
G L Pittman, and
R S Kyler, and
R I Roelofs, and
J N Whitaker, and
T E Bertorini
April 1992,
The New England journal of medicine,
J R Mendell, and
J T Kissel, and
M S Kennedy, and
Z Sahenk, and
H T Grinvalsky, and
G L Pittman, and
R S Kyler, and
R I Roelofs, and
J N Whitaker, and
T E Bertorini
January 1997,
Lancet (London, England),
J R Mendell, and
J T Kissel, and
M S Kennedy, and
Z Sahenk, and
H T Grinvalsky, and
G L Pittman, and
R S Kyler, and
R I Roelofs, and
J N Whitaker, and
T E Bertorini
January 1990,
Annales de medecine interne,
J R Mendell, and
J T Kissel, and
M S Kennedy, and
Z Sahenk, and
H T Grinvalsky, and
G L Pittman, and
R S Kyler, and
R I Roelofs, and
J N Whitaker, and
T E Bertorini
July 1985,
Lancet (London, England),
J R Mendell, and
J T Kissel, and
M S Kennedy, and
Z Sahenk, and
H T Grinvalsky, and
G L Pittman, and
R S Kyler, and
R I Roelofs, and
J N Whitaker, and
T E Bertorini
January 1985,
Journal of clinical apheresis,
J R Mendell, and
J T Kissel, and
M S Kennedy, and
Z Sahenk, and
H T Grinvalsky, and
G L Pittman, and
R S Kyler, and
R I Roelofs, and
J N Whitaker, and
T E Bertorini
September 1981,
British medical journal (Clinical research ed.),
J R Mendell, and
J T Kissel, and
M S Kennedy, and
Z Sahenk, and
H T Grinvalsky, and
G L Pittman, and
R S Kyler, and
R I Roelofs, and
J N Whitaker, and
T E Bertorini
February 1984,
Minerva medica,
J R Mendell, and
J T Kissel, and
M S Kennedy, and
Z Sahenk, and
H T Grinvalsky, and
G L Pittman, and
R S Kyler, and
R I Roelofs, and
J N Whitaker, and
T E Bertorini
January 1982,
Nursing times,
J R Mendell, and
J T Kissel, and
M S Kennedy, and
Z Sahenk, and
H T Grinvalsky, and
G L Pittman, and
R S Kyler, and
R I Roelofs, and
J N Whitaker, and
T E Bertorini
August 1989,
Journal of the Royal Society of Medicine,
