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In a single-blind randomized placebo-controlled cross-over study in hypertensive patients we have examined the effects of treatment with the non-selective beta-adrenoceptor antagonist nadolol on the responses of glucose, intermediary metabolites and the hormones of the enteroinsular axis to the ingestion of a mixed meal. During treatment with nadolol the plasma insulin concentration 30 min after ingesting the meal was significantly lower than on placebo and the plasma glucose rose more slowly. Plasma concentrations of GIP tended to be higher during nadolol than placebo treatment. No significant effects of treatment with nadolol were noted on pancreatic glucagon or intermediary metabolites.
N R Peden, and
R J Dow, and
T E Isles, and
B T Martin, and
K F Yee, and
K D Buchanan
December 1988,
Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
N R Peden, and
R J Dow, and
T E Isles, and
B T Martin, and
K F Yee, and
K D Buchanan
March 1993,
Methods and findings in experimental and clinical pharmacology,
N R Peden, and
R J Dow, and
T E Isles, and
B T Martin, and
K F Yee, and
K D Buchanan
July 1988,
British journal of pharmacology,
N R Peden, and
R J Dow, and
T E Isles, and
B T Martin, and
K F Yee, and
K D Buchanan
September 1987,
Scandinavian journal of clinical and laboratory investigation,
N R Peden, and
R J Dow, and
T E Isles, and
B T Martin, and
K F Yee, and
K D Buchanan
November 2000,
Arzneimittel-Forschung,
N R Peden, and
R J Dow, and
T E Isles, and
B T Martin, and
K F Yee, and
K D Buchanan
January 1987,
Patologicheskaia fiziologiia i eksperimental'naia terapiia,
N R Peden, and
R J Dow, and
T E Isles, and
B T Martin, and
K F Yee, and
K D Buchanan
January 2005,
Menopause (New York, N.Y.),
N R Peden, and
R J Dow, and
T E Isles, and
B T Martin, and
K F Yee, and
K D Buchanan
September 2001,
The journals of gerontology. Series A, Biological sciences and medical sciences,
N R Peden, and
R J Dow, and
T E Isles, and
B T Martin, and
K F Yee, and
K D Buchanan
April 1989,
Naunyn-Schmiedeberg's archives of pharmacology,
N R Peden, and
R J Dow, and
T E Isles, and
B T Martin, and
K F Yee, and
K D Buchanan
September 1979,
Gut,
