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Previous reports have described hormone-stimulated release of radiolabeled guanine nucleotides from prelabeled membranes. In this paper, we report the inhibition by GDP of both hormone-independent and hormone-specific stimulation of [3H]Gpp(NH)p release from human platelet membranes. This inhibition was shown to be concentration specific and suggests a more complex mechanism of [3H]Gpp(NH)p release than was previously thought. A model is proposed in which guanosin triphosphates cause dissociation of the subunits of the guanine nucleotide binding protein, whereas guanosine diphosphate prevents this dissociation resulting respectively in stimulation or inhibition of the release of bound [3H]Gpp(NH)p.
L M Banta, and
F R Bühler, and
E Bürgisser
February 1977,
Journal of cyclic nucleotide research,
L M Banta, and
F R Bühler, and
E Bürgisser
February 1992,
Neuroscience letters,
L M Banta, and
F R Bühler, and
E Bürgisser
August 1999,
Neuroreport,
L M Banta, and
F R Bühler, and
E Bürgisser
October 1998,
Neuroreport,
L M Banta, and
F R Bühler, and
E Bürgisser
July 1987,
Naunyn-Schmiedeberg's archives of pharmacology,
L M Banta, and
F R Bühler, and
E Bürgisser
November 1996,
Brain research. Molecular brain research,
L M Banta, and
F R Bühler, and
E Bürgisser
January 1984,
International journal of nuclear medicine and biology,
L M Banta, and
F R Bühler, and
E Bürgisser
June 1993,
Synapse (New York, N.Y.),
L M Banta, and
F R Bühler, and
E Bürgisser
January 1986,
The Japanese journal of physiology,
L M Banta, and
F R Bühler, and
E Bürgisser
October 1983,
Biochemical and biophysical research communications,
