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Only rarely has lymphoma been associated with ulcerative colitis. We report a 25-year-old man with an 8-year history of ulcerative colitis, who developed diffuse large cell lymphoma (histiocytic) of the colon. We review 17 previously reported cases and discuss the risk of lymphoma, diagnostic clues, prognosis, and the evidence for a relationship between ulcerative colitis and lymphoma.
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