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The influence of glucose, insulin and/or dexamethasone on the 7-ethoxycoumarin O-deethylase activity of rat hepatocytes in primary culture was investigated. The addition of extra glucose to the medium attenuated the fall in enzyme activity observed during the first 24 h in culture, this effect being dose-dependent. The inclusion of insulin further enhanced this effect, but glucose + insulin did not prevent the decrease in enzyme activity in the subsequent 48 h. The inclusion of dexamethasone, alone or in combination with glucose + insulin, also attentuated the initial decline in enzyme activity. After 24 h in culture, the enzyme activity increased such that after 72 h in culture, the activity was greater than that measured in the freshly isolated cells.
M Warren, and
J R Fry, and
M Balls
September 1986,
Xenobiotica; the fate of foreign compounds in biological systems,
M Warren, and
J R Fry, and
M Balls
February 1980,
Biochemical pharmacology,
M Warren, and
J R Fry, and
M Balls
July 1993,
International journal of oncology,
M Warren, and
J R Fry, and
M Balls
January 1990,
Archives of toxicology,
M Warren, and
J R Fry, and
M Balls
March 1986,
Xenobiotica; the fate of foreign compounds in biological systems,
M Warren, and
J R Fry, and
M Balls
October 1997,
Toxicology in vitro : an international journal published in association with BIBRA,
M Warren, and
J R Fry, and
M Balls
February 1988,
Pharmacology & toxicology,
M Warren, and
J R Fry, and
M Balls
December 1981,
Biochemical pharmacology,
M Warren, and
J R Fry, and
M Balls
March 1994,
Xenobiotica; the fate of foreign compounds in biological systems,
M Warren, and
J R Fry, and
M Balls
January 1991,
Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR,
