-transparent.png){kind=logo}
Oval cells isolated from livers of rats fed a choline-deficient diet containing 0.1% DL-ethionine (CDE) have an alkaline phosphatase (ALKP) isozyme which can be distinguished by its electrophoretic mobility from the enzyme present in parenchymal cells isolated from normal liver or livers of rats fed the CDE diet for 4 weeks. The oval cell ALKP has the same electrophoretic mobility as the enzyme from fetal rat liver and placenta. ALKPs from oval cells, parenchymal cells, and placenta all differ from the intestinal enzyme by their electrophoretic mobility, isoelectric focusing, and the patterns of amino acid inhibition of enzyme activity. Oval cells in preneoplastic livers, fetal hepatocytes, and tumor cells of a primary hepatocellular carcinoma induced by CDE feeding stained with a monoclonal antibody directed against rat placental ALKP. Hepatocytes (in normal or preneoplastic livers) and bile duct cells in normal liver did not stain with the same antibody. Placental ALKP may thus be a useful marker in tracing the origin and fate of oval cells during hepatocarcinogenesis.
P Yaswen, and
N L Thompson, and
N Fausto
January 1988,
Anticancer research,
P Yaswen, and
N L Thompson, and
N Fausto
January 1985,
Zeitschrift fur mikroskopisch-anatomische Forschung,
P Yaswen, and
N L Thompson, and
N Fausto
August 1975,
Annals of the New York Academy of Sciences,
P Yaswen, and
N L Thompson, and
N Fausto
December 1974,
Cancer research,
P Yaswen, and
N L Thompson, and
N Fausto
September 2007,
Matrix biology : journal of the International Society for Matrix Biology,
P Yaswen, and
N L Thompson, and
N Fausto
January 1984,
Progress in clinical and biological research,
P Yaswen, and
N L Thompson, and
N Fausto
January 1987,
Advances in cancer research,
P Yaswen, and
N L Thompson, and
N Fausto
February 1996,
Zhonghua fu chan ke za zhi,
P Yaswen, and
N L Thompson, and
N Fausto
August 1979,
Experimental cell research,
P Yaswen, and
N L Thompson, and
N Fausto
July 1955,
The Journal of biophysical and biochemical cytology,
