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A randomised double blind controlled trial was conducted to see whether vitamin A supplementation in the form of retinyl palmitate would increase the concentrations of serum retinol and retinol binding protein. A total of 376 people were studied and were allocated to one of 7 regimens covering doses of vitamin A from O (placebo) to 36,000 IU daily. Supplementation continued for 6 months and blood samples were collected immediately before the start of supplementation, after 3 months and after 6 months. There was a small but statistically significant increase in serum retinol levels associated with supplementation, but no significant increase in serum retinol binding protein. The extent of the increase in serum retinol was related to the extent of the supplementation. On average, for every 10,000 IU of retinyl palmitate per day, the serum retinol concentration increased by 13 micrograms/l after 3 months (an increase of 2%) and 12 micrograms/l after 6 months of supplementation (2% increase). All the regimens used showed no evidence of toxicity other than minor symptomatic and physical changes affecting the skin and mucous membranes.
N J Wald, and
H S Cuckle, and
R D Barlow, and
P Thompson, and
K Nanchahal, and
R J Blow, and
I Brown, and
C C Harling, and
W J McCulloch, and
J Morgan
April 1979,
Clinica chimica acta; international journal of clinical chemistry,
N J Wald, and
H S Cuckle, and
R D Barlow, and
P Thompson, and
K Nanchahal, and
R J Blow, and
I Brown, and
C C Harling, and
W J McCulloch, and
J Morgan
January 1979,
Acta paediatrica Scandinavica,
N J Wald, and
H S Cuckle, and
R D Barlow, and
P Thompson, and
K Nanchahal, and
R J Blow, and
I Brown, and
C C Harling, and
W J McCulloch, and
J Morgan
June 1979,
The American journal of clinical nutrition,
N J Wald, and
H S Cuckle, and
R D Barlow, and
P Thompson, and
K Nanchahal, and
R J Blow, and
I Brown, and
C C Harling, and
W J McCulloch, and
J Morgan
September 2002,
The Journal of nutrition,
N J Wald, and
H S Cuckle, and
R D Barlow, and
P Thompson, and
K Nanchahal, and
R J Blow, and
I Brown, and
C C Harling, and
W J McCulloch, and
J Morgan
June 1985,
Clinica chimica acta; international journal of clinical chemistry,
N J Wald, and
H S Cuckle, and
R D Barlow, and
P Thompson, and
K Nanchahal, and
R J Blow, and
I Brown, and
C C Harling, and
W J McCulloch, and
J Morgan
August 1989,
Endocrine reviews,
N J Wald, and
H S Cuckle, and
R D Barlow, and
P Thompson, and
K Nanchahal, and
R J Blow, and
I Brown, and
C C Harling, and
W J McCulloch, and
J Morgan
March 1979,
The Southeast Asian journal of tropical medicine and public health,
N J Wald, and
H S Cuckle, and
R D Barlow, and
P Thompson, and
K Nanchahal, and
R J Blow, and
I Brown, and
C C Harling, and
W J McCulloch, and
J Morgan
March 1981,
The British journal of nutrition,
N J Wald, and
H S Cuckle, and
R D Barlow, and
P Thompson, and
K Nanchahal, and
R J Blow, and
I Brown, and
C C Harling, and
W J McCulloch, and
J Morgan
January 1974,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
N J Wald, and
H S Cuckle, and
R D Barlow, and
P Thompson, and
K Nanchahal, and
R J Blow, and
I Brown, and
C C Harling, and
W J McCulloch, and
J Morgan
January 2016,
The Journal of dermatological treatment,
