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The pharmacokinetics of ceftazidime, a new cephalosporin antibiotic, were studied in 7 healthy volunteers and 32 patients with renal insufficiency after a single 500-mg intravenous injection. The mean plasma half-life during beta-phase was 1.67 h in normal subjects and was prolonged to 15.09 h in hemodialysis patients. There were significant correlations between the elimination rate constant and the creatinine clearance, and between the beta-phase rate constant and the creatinine clearance. The mean urinary recovery during 24 h amounted to 89.6% of the dose in normal subjects and decreased with the lowering of renal function. The plasma levels during hemodialysis were lower than those between hemodialyses.
M Ohkawa, and
T Nakashima, and
R Shoda, and
A Ikeda, and
M Orito, and
M Sawaki, and
T Sugata, and
M Shimamura, and
S Hirano, and
K Okumura
February 1984,
Antimicrobial agents and chemotherapy,
M Ohkawa, and
T Nakashima, and
R Shoda, and
A Ikeda, and
M Orito, and
M Sawaki, and
T Sugata, and
M Shimamura, and
S Hirano, and
K Okumura
January 1979,
Therapie,
M Ohkawa, and
T Nakashima, and
R Shoda, and
A Ikeda, and
M Orito, and
M Sawaki, and
T Sugata, and
M Shimamura, and
S Hirano, and
K Okumura
October 1983,
Antimicrobial agents and chemotherapy,
M Ohkawa, and
T Nakashima, and
R Shoda, and
A Ikeda, and
M Orito, and
M Sawaki, and
T Sugata, and
M Shimamura, and
S Hirano, and
K Okumura
December 1986,
Antimicrobial agents and chemotherapy,
M Ohkawa, and
T Nakashima, and
R Shoda, and
A Ikeda, and
M Orito, and
M Sawaki, and
T Sugata, and
M Shimamura, and
S Hirano, and
K Okumura
November 1984,
Antimicrobial agents and chemotherapy,
M Ohkawa, and
T Nakashima, and
R Shoda, and
A Ikeda, and
M Orito, and
M Sawaki, and
T Sugata, and
M Shimamura, and
S Hirano, and
K Okumura
June 1991,
Antimicrobial agents and chemotherapy,
M Ohkawa, and
T Nakashima, and
R Shoda, and
A Ikeda, and
M Orito, and
M Sawaki, and
T Sugata, and
M Shimamura, and
S Hirano, and
K Okumura
January 2009,
International journal of clinical pharmacology and therapeutics,
M Ohkawa, and
T Nakashima, and
R Shoda, and
A Ikeda, and
M Orito, and
M Sawaki, and
T Sugata, and
M Shimamura, and
S Hirano, and
K Okumura
December 1994,
The American journal of cardiology,
M Ohkawa, and
T Nakashima, and
R Shoda, and
A Ikeda, and
M Orito, and
M Sawaki, and
T Sugata, and
M Shimamura, and
S Hirano, and
K Okumura
October 2001,
Cornea,
M Ohkawa, and
T Nakashima, and
R Shoda, and
A Ikeda, and
M Orito, and
M Sawaki, and
T Sugata, and
M Shimamura, and
S Hirano, and
K Okumura
March 1995,
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic],
