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Of the two major subfractions of high density lipoprotein (HDL), HDL2 cholesterol (HDL2-C) and not HDL3 cholesterol (HDL3-C) correlates negatively with coronary heart disease. To study the effect of cimetidine and ranitidine on HDL subfractions, 6 healthy males received cimetidine (600 mg bid) ranitidine (150 mg bid) and placebo (one tab bid) for 1 week each, in random order. Measurements of HDL cholesterol (HDL-C), HDL2-C, HDL3-C were made on day 7 of each week. Comparing cimetidine with placebo, HDL2-C/HDL-C, HDL2-C/total cholesterol and HDL2-C/HDL3-C increased significantly while HDL3-C/HDL-C decreased. There was no difference in HDL-C parameters between ranitidine and placebo. Cimetidine treatment results in redistribution of HDL subfractions in favour of HDL2. The mechanism is not H2-receptor antagonism as ranitidine had no such effect.
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N R Peden, and
M C Champion, and
E I Simo
March 1985,
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T C Ooi, and
N R Peden, and
M C Champion, and
E I Simo
January 2002,
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T C Ooi, and
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January 1988,
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T C Ooi, and
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E I Simo
September 1994,
Clinical chemistry,
T C Ooi, and
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E I Simo
June 1993,
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T C Ooi, and
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E I Simo
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T C Ooi, and
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E I Simo
June 2009,
Atherosclerosis,
T C Ooi, and
N R Peden, and
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E I Simo
October 1998,
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T C Ooi, and
N R Peden, and
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E I Simo
February 1988,
Alcoholism, clinical and experimental research,
T C Ooi, and
N R Peden, and
M C Champion, and
E I Simo
January 1987,
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