-transparent.png){kind=logo}
The effect of chronic ethanol administration on 1, 2-dimethylhydrazine-induced rectal carcinogenesis was investigated in 32 paired male Sprague-Dawley rats fed a nutritionally-adequate liquid diet containing 36% of the total calories as either ethanol or isocaloric carbohydrates. Chronic ethanol ingestion increased the total number of rectal tumors significantly (17 vs 6; P less than 0.02), whereas no cocarcinogenic effect of ethanol was observed in other parts of the intestine. Alcohol did not influence tumor size or histopathology. A 47% increase in the activity of mucosal alcohol dehydrogenase in the distal colorectal region was found between chronically-ethanol-fed rats and pair-fed controls (0.241 +/- 0.019 vs 0.164 +/- 0.020 mumol/mg of protein/hr; P less than 0.01). This could in part explain the cocarcinogenic effect of alcohol in this tissue. Faecal bile acids, however, do not play a role as promotors of rectal carcinogenesis under the present experimental conditions. The results give experimental support to the epidemiologic findings of an increased incidence of rectal cancer in the alcoholic.
H K Seitz, and
P Czygan, and
U Simanowski, and
R Waldherr, and
S Veith, and
R Raedsch, and
B Kommerell
April 1989,
Drug and alcohol dependence,
H K Seitz, and
P Czygan, and
U Simanowski, and
R Waldherr, and
S Veith, and
R Raedsch, and
B Kommerell
June 1972,
Physiology & behavior,
H K Seitz, and
P Czygan, and
U Simanowski, and
R Waldherr, and
S Veith, and
R Raedsch, and
B Kommerell
January 1985,
Teratogenesis, carcinogenesis, and mutagenesis,
H K Seitz, and
P Czygan, and
U Simanowski, and
R Waldherr, and
S Veith, and
R Raedsch, and
B Kommerell
March 1989,
Carcinogenesis,
H K Seitz, and
P Czygan, and
U Simanowski, and
R Waldherr, and
S Veith, and
R Raedsch, and
B Kommerell
February 2003,
The Proceedings of the Nutrition Society,
H K Seitz, and
P Czygan, and
U Simanowski, and
R Waldherr, and
S Veith, and
R Raedsch, and
B Kommerell
February 1989,
Carcinogenesis,
H K Seitz, and
P Czygan, and
U Simanowski, and
R Waldherr, and
S Veith, and
R Raedsch, and
B Kommerell
May 1980,
Biochemical pharmacology,
H K Seitz, and
P Czygan, and
U Simanowski, and
R Waldherr, and
S Veith, and
R Raedsch, and
B Kommerell
February 1989,
Alcoholism, clinical and experimental research,
H K Seitz, and
P Czygan, and
U Simanowski, and
R Waldherr, and
S Veith, and
R Raedsch, and
B Kommerell
May 1976,
The Western journal of medicine,
H K Seitz, and
P Czygan, and
U Simanowski, and
R Waldherr, and
S Veith, and
R Raedsch, and
B Kommerell
January 1998,
Roczniki Panstwowego Zakladu Higieny,
