-transparent.png){kind=logo}
Endotoxin-induced cells of the reticuloendothelial system were shown to produce mediator(s) that evoke a state of cachexia in recipient animals. The factor(s) responsible were assayed in endotoxin-resistant (C3H/HeJ) mice, which were injected with dialyzed conditioned medium obtained from lipopolysaccharide-induced peritoneal macrophages. The mice exhibited weight loss and anorexia, and they died if sufficient quantities of medium were administered. The syndrome was reversible if injections were discontinued. Endotoxin alone did not produce this effect, and no gross pathologic lesions were discernable in the treated animals. In this model system, cachexia appears to result from the action of soluble macromolecules produced by activated macrophages in vitro. Cachectin (murine tumor necrosis factor) is thought to play a central role in this phenomenon.
A Cerami, and
Y Ikeda, and
N Le Trang, and
P J Hotez, and
B Beutler
September 1990,
Biochemistry,
A Cerami, and
Y Ikeda, and
N Le Trang, and
P J Hotez, and
B Beutler
September 1988,
The American journal of pathology,
A Cerami, and
Y Ikeda, and
N Le Trang, and
P J Hotez, and
B Beutler
March 1990,
Circulatory shock,
A Cerami, and
Y Ikeda, and
N Le Trang, and
P J Hotez, and
B Beutler
January 1986,
Immunologic research,
A Cerami, and
Y Ikeda, and
N Le Trang, and
P J Hotez, and
B Beutler
September 1987,
Science (New York, N.Y.),
A Cerami, and
Y Ikeda, and
N Le Trang, and
P J Hotez, and
B Beutler
January 1990,
Acta haematologica Polonica,
A Cerami, and
Y Ikeda, and
N Le Trang, and
P J Hotez, and
B Beutler
June 1996,
JPMA. The Journal of the Pakistan Medical Association,
A Cerami, and
Y Ikeda, and
N Le Trang, and
P J Hotez, and
B Beutler
May 1986,
Science (New York, N.Y.),
A Cerami, and
Y Ikeda, and
N Le Trang, and
P J Hotez, and
B Beutler
October 1989,
Cancer cells (Cold Spring Harbor, N.Y. : 1989),
A Cerami, and
Y Ikeda, and
N Le Trang, and
P J Hotez, and
B Beutler
July 1988,
Cell,
