Biomaterial Database

[Prophylactic antibiotic therapy using oxacillin in peripheral vascular surgery of the lower limbs. Preliminary results]. 1985

P Canton, and A Probst, and J P Génin, and J L Schmit, and M C Laxenaire

The rate of postoperative infections in lower limb vascular surgery was first evaluated in a retrospective study of 416 bypass procedures (68 venous grafts and 348 prosthetic grafts) in 400 patients seen over a two-year period. 31 postoperative infections (7.4%) were found. Outcome was fatal in three cases. 70% of cases were due to a methicillin-susceptible Staphylococcus aureus. Antibiotic prophylaxis with oxacillin given during surgery and for the first 48 postoperative hours was used for the next 112 procedures (17 venous grafts and 95 prosthetic grafts) in 107 patients. The preliminary results show a fall in the rate of postoperative infection, with only 5 cases (4.4%). The only case due to a methicillin-susceptible Staphylococcus occurred after a second surgical procedure without antibiotic prophylaxis. These preliminary results are promising although the difference does not reach statistical significance. However, it is of note that no patient undergoing vascular surgery for the first time developed postoperative infection. Further prospective studies are needed to determine the optimal antibiotic prophylaxis in lower limb vascular surgery.

UI	MeSH Term	Description	Entries
D007866	Leg	The inferior part of the lower extremity between the KNEE and the ANKLE.	Legs
D010068	Oxacillin	An antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections.	Oxazocilline,Penicillin, Methylphenylisoxazolyl,Sodium Oxacillin,Oxacillin Sodium,Oxacillin, Monosodium Salt, Anhydrous,Oxacillin, Monosodium Salt, Monohydrate,Prostaphlin,Methylphenylisoxazolyl Penicillin,Oxacillin, Sodium,Sodium, Oxacillin
D011183	Postoperative Complications	Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.	Complication, Postoperative,Complications, Postoperative,Postoperative Complication
D011292	Premedication	Preliminary administration of a drug preceding a diagnostic, therapeutic, or surgical procedure. The commonest types of premedication are antibiotics (ANTIBIOTIC PROPHYLAXIS) and anti-anxiety agents. It does not include PREANESTHETIC MEDICATION.	Premedications
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001424	Bacterial Infections	Infections by bacteria, general or unspecified.	Bacterial Disease,Bacterial Infection,Infection, Bacterial,Infections, Bacterial,Bacterial Diseases
D012189	Retrospective Studies	Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.	Retrospective Study,Studies, Retrospective,Study, Retrospective
D013203	Staphylococcal Infections	Infections with bacteria of the genus STAPHYLOCOCCUS.	Infections, Staphylococcal,Staphylococcus aureus Infection,Staphylococcal Infection,Staphylococcus aureus Infections
D014652	Vascular Diseases	Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ARTERIES; VEINS; and rest of the vasculature system in the body.	Disease, Vascular,Diseases, Vascular,Vascular Disease