-transparent.png){kind=logo}
The pharmacokinetics of ceftazidime after a 1-g bolus dose were studied in six elderly volunteers and 12 young subjects. Serum and urine samples were collected in serial order for 24 h and assayed by high-pressure liquid chromatography. The ceftazidime renal clearance was reduced in elderly subjects, a symptom related to normal aging of the kidneys. The decrease in volume of distribution in the elderly group may be explained by a reduction in total body water and an increase in fat tissue. Dosage adjustment is probably not necessary for otherwise healthy elderly patients requiring ceftazidime.
Related Publications
M LeBel, and
G Barbeau, and
F Vallee, and
M G Bergeron
January 1984,
Scandinavian journal of infectious diseases,
M LeBel, and
G Barbeau, and
F Vallee, and
M G Bergeron
January 1989,
Clinical pharmacy,
M LeBel, and
G Barbeau, and
F Vallee, and
M G Bergeron
June 1983,
Antimicrobial agents and chemotherapy,
M LeBel, and
G Barbeau, and
F Vallee, and
M G Bergeron
September 1981,
The Journal of antimicrobial chemotherapy,
M LeBel, and
G Barbeau, and
F Vallee, and
M G Bergeron
July 1983,
The Journal of antimicrobial chemotherapy,
M LeBel, and
G Barbeau, and
F Vallee, and
M G Bergeron
January 1980,
Communications in psychopharmacology,
M LeBel, and
G Barbeau, and
F Vallee, and
M G Bergeron
January 1992,
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology,
M LeBel, and
G Barbeau, and
F Vallee, and
M G Bergeron
April 1991,
Arzneimittel-Forschung,
M LeBel, and
G Barbeau, and
F Vallee, and
M G Bergeron
February 1985,
British journal of clinical pharmacology,
M LeBel, and
G Barbeau, and
F Vallee, and
M G Bergeron
January 2000,
European journal of drug metabolism and pharmacokinetics,
