Biomaterial Database

Tissue levels in patients after intravenous administration of ceftazidime. 1985

L H Loebis

Surgical patients (15 gynaecological and 58 other operative cases) were given 2 g of ceftazidime iv preoperatively. The ceftazidime levels of tissues removed during operation were determined. Levels were also determined from serum samples taken 30 min, 1 h, 3 h and 7 h post dosing. Tissue/serum ratios were calculated on the basis of the serum level at the time of removal of the tissue. For the myometrium, skeletal muscle, prostate, skin, gallbladder wall, breast, peritoneal tissue and fatty tissue these ratios were: 0.632 +/- 0.14, 0.600 +/- 0.18, 0.579 +/- 0.14, 0.441 +/- 0.18, 0.413 +/- 0.16, 0.368 +/- 0.15, 0.305 +/- 0.13 and 0.224 +/- 0.10 respectively. These ratios are higher than those reported in the literature. The possible reason for this discrepancy is discussed.

UI	MeSH Term	Description	Entries
D007263	Infusions, Parenteral	The administration of liquid medication, nutrient, or other fluid through some other route than the alimentary canal, usually over minutes or hours, either by gravity flow or often by infusion pumping.	Intra-Abdominal Infusions,Intraperitoneal Infusions,Parenteral Infusions,Peritoneal Infusions,Infusion, Intra-Abdominal,Infusion, Intraperitoneal,Infusion, Parenteral,Infusion, Peritoneal,Infusions, Intra-Abdominal,Infusions, Intraperitoneal,Infusions, Peritoneal,Intra Abdominal Infusions,Intra-Abdominal Infusion,Intraperitoneal Infusion,Parenteral Infusion,Peritoneal Infusion
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D002442	Ceftazidime	Semisynthetic, broad-spectrum antibacterial derived from CEPHALORIDINE and used especially for Pseudomonas and other gram-negative infections in debilitated patients.	Ceftazidime Anhydrous,Ceftazidime Pentahydrate,Fortaz,Fortum,GR-20263,LY-139381,Pyridinium, 1-((7-(((2-amino-4-thiazolyl)((1-carboxy-1-methylethoxy)imino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-, inner salt, pentahydrate, (6R-(6alpha,7beta(Z)))-,Tazidime,GR 20263,GR20263,LY 139381,LY139381
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly
D014018	Tissue Distribution	Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.	Distribution, Tissue,Distributions, Tissue,Tissue Distributions