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Specific high-titer antibodies to rat kidney renin were raised using pure rat kidney renin conjugated with tetanus toxoid as antigen. The titers of two antisera for 50% inhibition of rat kidney renin activity were 80 000 and 700 000, respectively. The antibody inhibited the enzyme activities of hog kidney renin and mouse submaxillary gland renin at concentrations 1 000 times higher than required for rat kidney renin but did not inhibit human renal renin or rat kidney cathepsin D. The antibody can be used for characterizing the physiological and pathophysiological role of renin in blood pressure regulation, for the histochemical localization of renin in rat tissues and for distinguishing specific renin activity from the nonspecific renin-like activity of cathepsin D.
A F Figueiredo, and
T Inagami
July 2022,
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology,
A F Figueiredo, and
T Inagami
July 1993,
Toxicology in vitro : an international journal published in association with BIBRA,
A F Figueiredo, and
T Inagami
October 1987,
Ceskoslovenska epidemiologie, mikrobiologie, imunologie,
A F Figueiredo, and
T Inagami
May 1962,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
A F Figueiredo, and
T Inagami
December 1980,
Clinical science (London, England : 1979),
A F Figueiredo, and
T Inagami
December 1984,
The Journal of biological chemistry,
A F Figueiredo, and
T Inagami
May 2001,
Current protocols in molecular biology,
A F Figueiredo, and
T Inagami
June 2005,
Hybridoma (2005),
A F Figueiredo, and
T Inagami
April 1995,
Clinical nephrology,
A F Figueiredo, and
T Inagami
April 1989,
Current protocols in molecular biology,
