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The glucagon-stimulated insulin and C-peptide release in patients with active acromegaly, cured acromegalic patients and healthy controls were studied. There was an elevation of the fasting insulin levels in active acromegalics and the fasting C-peptide levels in both patient groups. After i.v. injection of glucagon the insulin and C-peptide levels increased. The highest levels were recorded in active acromegalics, but cured patients also had higher levels than the control group. The insulin/C-peptide ratio was increased in active acromegalics in comparison with that found for inactive acromegalics and normal controls. In addition, the plasma half-lives (T1/2) of endogenous insulin and C-peptide were measured. It was found that the T1/2 for insulin was increased in active acromegalics only. From this study we conclude that even when the treatment of acromegaly is effective insulin and C-peptide secretion do not normalize due, probably, to increased synthesis and release upon stimulation of the pancreatic beta-cells. In active acromegaly the removal of insulin is probably also reduced.
F Roelfsema, and
M Frölich, and
P H Geelhoed-Duyvestijn, and
A C Nieuwenhuijzen Kruseman, and
B J Looij
January 1987,
Diabetes care,
F Roelfsema, and
M Frölich, and
P H Geelhoed-Duyvestijn, and
A C Nieuwenhuijzen Kruseman, and
B J Looij
January 1987,
Acta medica Scandinavica,
F Roelfsema, and
M Frölich, and
P H Geelhoed-Duyvestijn, and
A C Nieuwenhuijzen Kruseman, and
B J Looij
January 1981,
Journal of endocrinological investigation,
F Roelfsema, and
M Frölich, and
P H Geelhoed-Duyvestijn, and
A C Nieuwenhuijzen Kruseman, and
B J Looij
April 1989,
Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques,
F Roelfsema, and
M Frölich, and
P H Geelhoed-Duyvestijn, and
A C Nieuwenhuijzen Kruseman, and
B J Looij
April 1988,
Diabetes care,
F Roelfsema, and
M Frölich, and
P H Geelhoed-Duyvestijn, and
A C Nieuwenhuijzen Kruseman, and
B J Looij
September 1977,
British medical journal,
F Roelfsema, and
M Frölich, and
P H Geelhoed-Duyvestijn, and
A C Nieuwenhuijzen Kruseman, and
B J Looij
May 1989,
Diabetologia,
F Roelfsema, and
M Frölich, and
P H Geelhoed-Duyvestijn, and
A C Nieuwenhuijzen Kruseman, and
B J Looij
June 1991,
Fish physiology and biochemistry,
F Roelfsema, and
M Frölich, and
P H Geelhoed-Duyvestijn, and
A C Nieuwenhuijzen Kruseman, and
B J Looij
September 1983,
Anales espanoles de pediatria,
F Roelfsema, and
M Frölich, and
P H Geelhoed-Duyvestijn, and
A C Nieuwenhuijzen Kruseman, and
B J Looij
March 1982,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
