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The putative role of the central nervous system in the maintenance of elevated blood pressure in patients with essential hypertension (EH) and renal hypertension [unilateral renal parenchymal disease (RPD) and unilateral renal artery stenosis (RAS)] was studied by investigating the cardiovascular and hormonal effects of the predominantly centrally acting sympatholytic agent, clonidine. Oral clonidine lowered blood pressure substantially in all three groups. Levels of plasma renin activity were unchanged in EH and RAS but progressively fell in RPD. Plasma noradrenaline levels fell in all three groups. Clonidine therefore reduced blood pressure to the same extent in three distinct groups of hypertensives, in two of which the initiating cause was undoubtedly renal. This indicates that, although the primary cause differed, a prominent factor sustaining hypertension may have been an increase or an inappropriate maintenance of central pressor mechanisms.
C J Mathias, and
A H Wilkinson, and
F A Stone, and
S Peart
October 1987,
Chinese medical journal,
C J Mathias, and
A H Wilkinson, and
F A Stone, and
S Peart
February 1983,
Chest,
C J Mathias, and
A H Wilkinson, and
F A Stone, and
S Peart
January 1986,
Clinical therapeutics,
C J Mathias, and
A H Wilkinson, and
F A Stone, and
S Peart
November 1984,
Clinical pharmacology and therapeutics,
C J Mathias, and
A H Wilkinson, and
F A Stone, and
S Peart
March 1974,
Arzneimittel-Forschung,
C J Mathias, and
A H Wilkinson, and
F A Stone, and
S Peart
May 1987,
Circulation,
C J Mathias, and
A H Wilkinson, and
F A Stone, and
S Peart
April 1983,
Orvosi hetilap,
C J Mathias, and
A H Wilkinson, and
F A Stone, and
S Peart
October 1984,
Southern medical journal,
C J Mathias, and
A H Wilkinson, and
F A Stone, and
S Peart
November 1991,
American journal of hypertension,
C J Mathias, and
A H Wilkinson, and
F A Stone, and
S Peart
October 1987,
Journal of the American College of Cardiology,
