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One hundred and ninety-eight Nigerian children who received weekly chemoprophylaxis with chloroquine from shortly after birth until the age of one year or two years and 185 age-matched controls were studied. Chemoprophylaxis with chloroquine was partially, but not completely, effective in controlling malaria. Clinical malaria was documented significantly less frequently in protected children than in control children, and only 9% of random blood films obtained from protected children were positive for Plasmodium falciparum while 41% of random blood films from control children were positive for this parasite. Mean malaria antibody levels were lower in protected than in control children; for ELISA and precipitin antibodies the difference between the two groups was less marked at two years than at one year. Mortality was similar among protected and among control children. No rebound mortality or morbidity was observed after chemoprophylaxis was stopped.
A M Bradley-Moore, and
B M Greenwood, and
A K Bradley, and
A Bartlett, and
D E Bidwell, and
A Voller, and
B R Kirkwood, and
H M Gilles
January 1993,
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
A M Bradley-Moore, and
B M Greenwood, and
A K Bradley, and
A Bartlett, and
D E Bidwell, and
A Voller, and
B R Kirkwood, and
H M Gilles
January 1995,
Transactions of the Royal Society of Tropical Medicine and Hygiene,
A M Bradley-Moore, and
B M Greenwood, and
A K Bradley, and
A Bartlett, and
D E Bidwell, and
A Voller, and
B R Kirkwood, and
H M Gilles
January 2003,
Bulletin of the World Health Organization,
A M Bradley-Moore, and
B M Greenwood, and
A K Bradley, and
A Bartlett, and
D E Bidwell, and
A Voller, and
B R Kirkwood, and
H M Gilles
March 1993,
African journal of medicine and medical sciences,
A M Bradley-Moore, and
B M Greenwood, and
A K Bradley, and
A Bartlett, and
D E Bidwell, and
A Voller, and
B R Kirkwood, and
H M Gilles
January 1999,
Transactions of the Royal Society of Tropical Medicine and Hygiene,
A M Bradley-Moore, and
B M Greenwood, and
A K Bradley, and
A Bartlett, and
D E Bidwell, and
A Voller, and
B R Kirkwood, and
H M Gilles
April 2000,
Antimicrobial agents and chemotherapy,
A M Bradley-Moore, and
B M Greenwood, and
A K Bradley, and
A Bartlett, and
D E Bidwell, and
A Voller, and
B R Kirkwood, and
H M Gilles
January 2000,
Pediatric surgery international,
A M Bradley-Moore, and
B M Greenwood, and
A K Bradley, and
A Bartlett, and
D E Bidwell, and
A Voller, and
B R Kirkwood, and
H M Gilles
August 1979,
The Medical letter on drugs and therapeutics,
A M Bradley-Moore, and
B M Greenwood, and
A K Bradley, and
A Bartlett, and
D E Bidwell, and
A Voller, and
B R Kirkwood, and
H M Gilles
March 1997,
Parasitology today (Personal ed.),
A M Bradley-Moore, and
B M Greenwood, and
A K Bradley, and
A Bartlett, and
D E Bidwell, and
A Voller, and
B R Kirkwood, and
H M Gilles
January 2011,
The West Indian medical journal,
