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Discovery of components of the renin-angiotensin system (RAS) in the adenohypophysis of several species has prompted speculation concerning the location and possible function of a pituitary RAS. Although both renin and angiotensin II have been localized within the rat adenohypophysis, their colocalization has not been previously demonstrated within the same cells. In the present study, immunohistochemical staining by the avidin-biotin-peroxidase complex technique was used to demonstrate the coexistence of renin and angiotensin II in adenohypophyseal cells identified morphologically and immunocytochemically as gonadotrophs. These results support the existence of an adenohypophyseal RAS, at least part of which is under intracellular control. The influence of this system on control of fluid balance, blood pressure, and the secretion of other hypophyseal hormones is discussed.
J C McKenzie, and
K Naruse, and
T Inagami
April 1989,
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J C McKenzie, and
K Naruse, and
T Inagami
July 1986,
Endocrinology,
J C McKenzie, and
K Naruse, and
T Inagami
January 1992,
Revista de medicina de la Universidad de Navarra,
J C McKenzie, and
K Naruse, and
T Inagami
June 1986,
Endocrinology,
J C McKenzie, and
K Naruse, and
T Inagami
January 1991,
Trends in endocrinology and metabolism: TEM,
J C McKenzie, and
K Naruse, and
T Inagami
February 1985,
The American journal of physiology,
J C McKenzie, and
K Naruse, and
T Inagami
January 2003,
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J C McKenzie, and
K Naruse, and
T Inagami
May 1978,
The Journal of physiology,
J C McKenzie, and
K Naruse, and
T Inagami
March 1990,
Acta endocrinologica,
J C McKenzie, and
K Naruse, and
T Inagami
January 1986,
Neuropeptides,
