-transparent.png){kind=logo}
Cyclosporine, a cyclic endecapeptide of fungal origin, has been used for nine years in clinical transplantation to suppress allograft rejection. Nephrotoxicity represents the most frequent and severe complication associated with its use and may ultimately define the limits of its utility as a drug for long term immunosuppression. However, this nephrotoxicity cannot be truly assessed in kidney transplant recipients for obvious reasons. It has recently been reported in heart transplant recipients. In addition, cyclosporine therapy is responsible for a persistent elevation of blood pressure requiring intensive and combined anti-hypertensive regimens. This hypertension develops within the first weeks post-transplantation in 60% to 90% of heart allograft recipients. This study analyzes the renal function and blood pressure of patients operated on in our department where cyclosporine was introduced in 1981.
J Rottembourg, and
M F Mattei, and
A Cabrol, and
P Leger, and
B Aupetit, and
H Beaufils, and
J C Gluckman, and
A Pavie, and
I Gandjbakhch, and
C Cabrol
December 1997,
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation,
J Rottembourg, and
M F Mattei, and
A Cabrol, and
P Leger, and
B Aupetit, and
H Beaufils, and
J C Gluckman, and
A Pavie, and
I Gandjbakhch, and
C Cabrol
December 1984,
Transplantation proceedings,
J Rottembourg, and
M F Mattei, and
A Cabrol, and
P Leger, and
B Aupetit, and
H Beaufils, and
J C Gluckman, and
A Pavie, and
I Gandjbakhch, and
C Cabrol
January 1994,
American journal of nephrology,
J Rottembourg, and
M F Mattei, and
A Cabrol, and
P Leger, and
B Aupetit, and
H Beaufils, and
J C Gluckman, and
A Pavie, and
I Gandjbakhch, and
C Cabrol
October 2001,
Transplantation,
J Rottembourg, and
M F Mattei, and
A Cabrol, and
P Leger, and
B Aupetit, and
H Beaufils, and
J C Gluckman, and
A Pavie, and
I Gandjbakhch, and
C Cabrol
June 1998,
Transplantation proceedings,
J Rottembourg, and
M F Mattei, and
A Cabrol, and
P Leger, and
B Aupetit, and
H Beaufils, and
J C Gluckman, and
A Pavie, and
I Gandjbakhch, and
C Cabrol
August 1992,
Transplantation proceedings,
J Rottembourg, and
M F Mattei, and
A Cabrol, and
P Leger, and
B Aupetit, and
H Beaufils, and
J C Gluckman, and
A Pavie, and
I Gandjbakhch, and
C Cabrol
February 1996,
Transplantation,
J Rottembourg, and
M F Mattei, and
A Cabrol, and
P Leger, and
B Aupetit, and
H Beaufils, and
J C Gluckman, and
A Pavie, and
I Gandjbakhch, and
C Cabrol
January 1990,
Transplantation,
J Rottembourg, and
M F Mattei, and
A Cabrol, and
P Leger, and
B Aupetit, and
H Beaufils, and
J C Gluckman, and
A Pavie, and
I Gandjbakhch, and
C Cabrol
April 2000,
Transplantation,
J Rottembourg, and
M F Mattei, and
A Cabrol, and
P Leger, and
B Aupetit, and
H Beaufils, and
J C Gluckman, and
A Pavie, and
I Gandjbakhch, and
C Cabrol
June 1992,
Transplantation,
