BIOMAT Database Logo BIOMAT Database Logo

Evidence for suppression of beta cell function by cyclosporin A. 1985

R van Schilfgaarde, and M P van der Burg, and H G Gooszen, and M Frölich, and W Felthuis
Department of Surgery, University Hospital, Leiden, The Netherlands.

UI MeSH Term Description Entries
D007328 Insulin A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D007515 Islets of Langerhans Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN. Islands of Langerhans,Islet Cells,Nesidioblasts,Pancreas, Endocrine,Pancreatic Islets,Cell, Islet,Cells, Islet,Endocrine Pancreas,Islet Cell,Islet, Pancreatic,Islets, Pancreatic,Langerhans Islands,Langerhans Islets,Nesidioblast,Pancreatic Islet
D010179 Pancreas A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
D001786 Blood Glucose Glucose in blood. Blood Sugar,Glucose, Blood,Sugar, Blood
D003524 Cyclosporins A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection. Cyclosporines
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog
D006085 Graft Survival The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host. Graft Survivals,Survival, Graft,Survivals, Graft
D000078790 Insulin Secretion Production and release of insulin from PANCREATIC BETA CELLS that primarily occurs in response to elevated BLOOD GLUCOSE levels. Secretion, Insulin
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014182 Transplantation, Autologous Transplantation of an individual's own tissue from one site to another site. Autografting,Autologous Transplantation,Autotransplantation,Autograftings,Autologous Transplantations,Autotransplantations,Transplantations, Autologous

Related Publications

R van Schilfgaarde, and M P van der Burg, and H G Gooszen, and M Frölich, and W Felthuis
Suppression of pancreatic beta cell function by cyclosporin.
August 1987, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
R van Schilfgaarde, and M P van der Burg, and H G Gooszen, and M Frölich, and W Felthuis
Suppression of B cell activation by cyclosporin A, FK506 and rapamycin.
October 1990, European journal of immunology,
R van Schilfgaarde, and M P van der Burg, and H G Gooszen, and M Frölich, and W Felthuis
Suppression of corneal allograft rejection by cyclosporin A.
September 1981, Archives of ophthalmology (Chicago, Ill. : 1960),
R van Schilfgaarde, and M P van der Burg, and H G Gooszen, and M Frölich, and W Felthuis
Suppression of experimental allergic neuritis by Cyclosporin-A.
January 1983, Acta neuropathologica,
R van Schilfgaarde, and M P van der Burg, and H G Gooszen, and M Frölich, and W Felthuis
Suppression of experimental allergic neuritis by cyclosporin A.
January 1988, Annals of the New York Academy of Sciences,
R van Schilfgaarde, and M P van der Burg, and H G Gooszen, and M Frölich, and W Felthuis
Evidence for a B-cell memory-forming factor (BMFF) able to reconstitute cyclosporin-A-induced suppression of the secondary response.
January 1987, Annales de l'Institut Pasteur. Immunology,
R van Schilfgaarde, and M P van der Burg, and H G Gooszen, and M Frölich, and W Felthuis
Electrophysiological evidence for histaminergic modulation of pancreatic beta-cell function.
January 1986, Advances in experimental medicine and biology,
R van Schilfgaarde, and M P van der Burg, and H G Gooszen, and M Frölich, and W Felthuis
Reversible suppression of allo-antibody production by cyclosporin A.
January 1980, International archives of allergy and applied immunology,
R van Schilfgaarde, and M P van der Burg, and H G Gooszen, and M Frölich, and W Felthuis
Suppression of ammonia-induced astrocyte swelling by cyclosporin A.
December 2003, Journal of neuroscience research,
R van Schilfgaarde, and M P van der Burg, and H G Gooszen, and M Frölich, and W Felthuis
Selective suppression of an early step in human B cell activation by cyclosporin A.
September 1983, The Journal of experimental medicine,
Copied contents to your clipboard!