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The long term in vivo effects of the recently characterized human pancreas GH-releasing factor, hpGRF (1-44) were studied in chronically cannulated unrestrained rats. In order to minimize the influence of endogenous hypothalamic GRF and somatostatin on the pituitary, the experiments were carried out in rats with the pituitary autotransplanted to the kidney capsule. The integrated GH release (mean +/- SE) in response to an iv injection of hpGRF (4 micrograms/kg) was markedly enhanced (P less than 0.01) by iv pretreatment with hpGRF every 8 h for 3 days (182 +/- 47 h X ng/ml) as compared to saline-pretreated controls (36 +/- 4 h X ng/ml). TRH pretreatment did not potentiate the effect of hpGRF (47 +/- 9 h X ng/ml). It is concluded that multiple administrations of hpGRF enhance the GH response to a subsequent hpGRF injection in the rat. Moreover, autotransplantation of the pituitary to the kidney capsule may supply a useful in vivo model for further studies on the effects of different modes of GRF administration on GH secretion.
J O Jansson, and
L Carlsson, and
O G Isaksson
April 1987,
European journal of pharmacology,
J O Jansson, and
L Carlsson, and
O G Isaksson
October 1987,
Endocrinology,
J O Jansson, and
L Carlsson, and
O G Isaksson
May 1987,
The Journal of endocrinology,
J O Jansson, and
L Carlsson, and
O G Isaksson
May 1965,
Acta endocrinologica,
J O Jansson, and
L Carlsson, and
O G Isaksson
June 1985,
Journal of endocrinological investigation,
J O Jansson, and
L Carlsson, and
O G Isaksson
January 1990,
Psychoneuroendocrinology,
J O Jansson, and
L Carlsson, and
O G Isaksson
January 1987,
Acta paediatrica Scandinavica,
J O Jansson, and
L Carlsson, and
O G Isaksson
January 1985,
Biochemical and biophysical research communications,
J O Jansson, and
L Carlsson, and
O G Isaksson
June 1988,
Nihon Ika Daigaku zasshi,
J O Jansson, and
L Carlsson, and
O G Isaksson
April 1993,
Journal of developmental physiology,
