-transparent.png){kind=logo}
Prostaglandins protect against aspirin-induced damage to the gastrointestinal tract. This study tested the ability of enprostil, a synthetic analog of prostaglandin E2, given concurrently to prevent gastroduodenal injury. Twenty-four healthy subjects were randomly assigned to one of three groups. All received aspirin 650 mg q.i.d. for 5 days. One group received placebo and the other groups were given either 7 or 70 micrograms of enprostil b.i.d. for 5 days. Upper endoscopy was performed at entry and 2 h after the final dose of aspirin. Enprostil 70 micrograms b.i.d. afforded significant protection of both the antral and duodenal mucosa. The 7-micrograms dose protected only the antral mucosa. Side effects were not observed with the lower dose of enprostil. Serum salicylate levels did not differ significantly between the groups.
M M Cohen, and
D R McCready, and
L Clark, and
H Sevelius
March 1986,
British medical journal (Clinical research ed.),
M M Cohen, and
D R McCready, and
L Clark, and
H Sevelius
January 1978,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
M M Cohen, and
D R McCready, and
L Clark, and
H Sevelius
July 1990,
Gastroenterology,
M M Cohen, and
D R McCready, and
L Clark, and
H Sevelius
February 2022,
Cancer prevention research (Philadelphia, Pa.),
M M Cohen, and
D R McCready, and
L Clark, and
H Sevelius
October 2014,
The Journal of allergy and clinical immunology,
M M Cohen, and
D R McCready, and
L Clark, and
H Sevelius
April 1986,
Gastrointestinal endoscopy,
M M Cohen, and
D R McCready, and
L Clark, and
H Sevelius
October 1984,
Scandinavian journal of gastroenterology,
M M Cohen, and
D R McCready, and
L Clark, and
H Sevelius
April 1987,
British medical journal (Clinical research ed.),
M M Cohen, and
D R McCready, and
L Clark, and
H Sevelius
May 1983,
Ugeskrift for laeger,
M M Cohen, and
D R McCready, and
L Clark, and
H Sevelius
March 2008,
Alimentary pharmacology & therapeutics,
