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Stimulation of human B lymphoblastoid cell lines, CESS and SKW6-CL4 with BCDF induced an increase in IgG- and IgM-secreting cells, as well as a slight increase in IgG and IgM expression on their respective surfaces. Biosynthetic labeling demonstrated that BCDF stimulation induced an increase in synthesis of secretory gamma- and mu-chains, as well as their precursors. A slight but significant increase in synthesis of membrane-bound gamma- and mu-chains and their precursors was also observed by BCDF stimulation. However, an increase in synthesis of secretory heavy chains was much higher than that in membrane-bound heavy chains in both cell lines. Pulse-chase experiments showed that increased synthesis of secretory heavy chains was not due to a decrease in degradation. BCDF stimulation induced a preferential increase in mRNA specific for secretory gamma- and mu-chains in CESS and SKW6-CL4 cells, respectively. These results suggest that BCDF induces an increase in the level of mRNA specific for secretory heavy chains, and then induces final maturation of B cells into immunoglobulin-secreting cells.
H Kikutani, and
T Taga, and
S Akira, and
H Kishi, and
Y Miki, and
O Saiki, and
Y Yamamura, and
T Kishimoto
January 1984,
Journal of immunology (Baltimore, Md. : 1950),
H Kikutani, and
T Taga, and
S Akira, and
H Kishi, and
Y Miki, and
O Saiki, and
Y Yamamura, and
T Kishimoto
June 1984,
Journal of immunology (Baltimore, Md. : 1950),
H Kikutani, and
T Taga, and
S Akira, and
H Kishi, and
Y Miki, and
O Saiki, and
Y Yamamura, and
T Kishimoto
August 1985,
Proceedings of the National Academy of Sciences of the United States of America,
H Kikutani, and
T Taga, and
S Akira, and
H Kishi, and
Y Miki, and
O Saiki, and
Y Yamamura, and
T Kishimoto
April 1987,
Immunology,
H Kikutani, and
T Taga, and
S Akira, and
H Kishi, and
Y Miki, and
O Saiki, and
Y Yamamura, and
T Kishimoto
July 1985,
Infection and immunity,
H Kikutani, and
T Taga, and
S Akira, and
H Kishi, and
Y Miki, and
O Saiki, and
Y Yamamura, and
T Kishimoto
October 1983,
Journal of immunology (Baltimore, Md. : 1950),
H Kikutani, and
T Taga, and
S Akira, and
H Kishi, and
Y Miki, and
O Saiki, and
Y Yamamura, and
T Kishimoto
December 1983,
Journal of immunology (Baltimore, Md. : 1950),
H Kikutani, and
T Taga, and
S Akira, and
H Kishi, and
Y Miki, and
O Saiki, and
Y Yamamura, and
T Kishimoto
November 1984,
Arerugi = [Allergy],
H Kikutani, and
T Taga, and
S Akira, and
H Kishi, and
Y Miki, and
O Saiki, and
Y Yamamura, and
T Kishimoto
September 1987,
Cellular immunology,
H Kikutani, and
T Taga, and
S Akira, and
H Kishi, and
Y Miki, and
O Saiki, and
Y Yamamura, and
T Kishimoto
December 1986,
Blood,
