-transparent.png){kind=logo}
The incidence of amikacin resistance among gram-negative bacilli isolated at the New York V.A. Medical Center increased from 2.0% to greater than 7% during an 18-month period from January 1980 to July 1981. This increase coincided with a threefold increase in amikacin use at this institution. The amikacin-resistant (AKR) isolates most frequently recovered in 1981 were species of Klebsiella, Serratia, and Pseudomonas. These organisms were recovered from multiple sites, including urine, sputum, wounds, blood, peritoneal fluid, and pleural fluid. The amikacin-modifying enzyme 6'-N-acetyltransferase was detected in 27 (67.5%) of 40 randomly selected AKR isolates. These data indicate that resistance to amikacin in this hospital is enzymatically mediated in most strains of AKR Klebsiella and Serratia and in about one-third of AKR strains of P. aeruginosa. This finding supports the conclusion that amikacin resistance is enhanced by the pressure of increased amikacin use.
J F Levine, and
M J Maslow, and
R E Leibowitz, and
A A Pollock, and
B A Hanna, and
S Schaefler, and
M S Simberkoff, and
J J Rahal
January 1979,
Bollettino dell'Istituto sieroterapico milanese,
J F Levine, and
M J Maslow, and
R E Leibowitz, and
A A Pollock, and
B A Hanna, and
S Schaefler, and
M S Simberkoff, and
J J Rahal
June 1986,
The American journal of medicine,
J F Levine, and
M J Maslow, and
R E Leibowitz, and
A A Pollock, and
B A Hanna, and
S Schaefler, and
M S Simberkoff, and
J J Rahal
June 1977,
The American journal of medicine,
J F Levine, and
M J Maslow, and
R E Leibowitz, and
A A Pollock, and
B A Hanna, and
S Schaefler, and
M S Simberkoff, and
J J Rahal
January 1988,
Chemotherapy,
J F Levine, and
M J Maslow, and
R E Leibowitz, and
A A Pollock, and
B A Hanna, and
S Schaefler, and
M S Simberkoff, and
J J Rahal
February 1976,
Lancet (London, England),
J F Levine, and
M J Maslow, and
R E Leibowitz, and
A A Pollock, and
B A Hanna, and
S Schaefler, and
M S Simberkoff, and
J J Rahal
June 1977,
The American journal of medicine,
J F Levine, and
M J Maslow, and
R E Leibowitz, and
A A Pollock, and
B A Hanna, and
S Schaefler, and
M S Simberkoff, and
J J Rahal
January 1977,
The American journal of the medical sciences,
J F Levine, and
M J Maslow, and
R E Leibowitz, and
A A Pollock, and
B A Hanna, and
S Schaefler, and
M S Simberkoff, and
J J Rahal
June 1975,
The Japanese journal of antibiotics,
J F Levine, and
M J Maslow, and
R E Leibowitz, and
A A Pollock, and
B A Hanna, and
S Schaefler, and
M S Simberkoff, and
J J Rahal
January 1976,
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases,
J F Levine, and
M J Maslow, and
R E Leibowitz, and
A A Pollock, and
B A Hanna, and
S Schaefler, and
M S Simberkoff, and
J J Rahal
November 1976,
The Journal of infectious diseases,
