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The possible role of thyrotrophin-releasing hormone (TRH) in causing the pro-oestrous surge of prolactin was investigated in conscious female rats by passive immunization with a specific anti-TRH serum raised in sheep. Blood samples were withdrawn through a previously implanted intra-atrial cannula. The i.p. injection of 1 ml anti-TRH serum, but not non-immune sheep serum, at 13.00 h of pro-oestrus delayed by about 1 h the onset of the prolactin surge, but the peak of the surge was similar to that in animals injected with the non-immune serum. The plasma concentrations of TSH were significantly reduced by the anti-TRH serum, but plasma concentrations of LH were not significantly affected. These results show that TRH may play an important role in the timing and initiation, but not the maintenance of the prolactin surge in the pro-oestrous rat.
A M Horn, and
H M Fraser, and
G Fink
April 1993,
The Journal of endocrinology,
A M Horn, and
H M Fraser, and
G Fink
October 1979,
Acta endocrinologica,
A M Horn, and
H M Fraser, and
G Fink
April 1974,
The Journal of endocrinology,
A M Horn, and
H M Fraser, and
G Fink
July 1973,
Clinical endocrinology,
A M Horn, and
H M Fraser, and
G Fink
October 1982,
Archives of disease in childhood,
A M Horn, and
H M Fraser, and
G Fink
July 1975,
Clinical endocrinology,
A M Horn, and
H M Fraser, and
G Fink
July 1980,
Postgraduate medical journal,
A M Horn, and
H M Fraser, and
G Fink
February 1983,
The Journal of endocrinology,
A M Horn, and
H M Fraser, and
G Fink
June 1974,
The Journal of endocrinology,
A M Horn, and
H M Fraser, and
G Fink
October 1984,
Acta endocrinologica,
