-transparent.png){kind=logo}
The kinetics of autologous 111In-labelled platelets were studied in 26 patients with ITP. The platelet mean life time (MLT) was considerably shortened, the platelet in vivo recovery slightly lowered and the platelet turnover normal. Comparative studies of the kinetics of simultaneously injected 111In- and 51Cr-labelled platelets in 10 patients showed the MLT and turnover of 51Cr-platelets to be shorter and higher, respectively, than those of 111In-platelets, suggesting that 51Cr-labelling in ITP may underestimate platelet MLT and overestimate platelet turnover. Our results confirm that accelerated platelet destruction is an important pathogenetic factor in ITP, and that the platelet concentration may be influenced by increased splenic platelet pooling and by inability of the bone marrow to respond adequately to the low platelet count. Our scintigraphic studies showed that the spleen played an important role for platelet destruction in most patients, with the liver contributing in some patients.
K G Schmidt, and
J W Rasmussen
August 1979,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
K G Schmidt, and
J W Rasmussen
January 1986,
Blood,
K G Schmidt, and
J W Rasmussen
May 2006,
European journal of haematology,
K G Schmidt, and
J W Rasmussen
January 2002,
Nuclear medicine review. Central & Eastern Europe,
K G Schmidt, and
J W Rasmussen
November 2002,
Wiener klinische Wochenschrift,
K G Schmidt, and
J W Rasmussen
July 1982,
La Nouvelle presse medicale,
K G Schmidt, and
J W Rasmussen
January 1972,
Lancet (London, England),
K G Schmidt, and
J W Rasmussen
November 2005,
Zhonghua yi xue za zhi,
K G Schmidt, and
J W Rasmussen
June 1997,
British journal of haematology,
K G Schmidt, and
J W Rasmussen
December 1983,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
