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Two independent methods were used to identify the mouse chromosomes on which are located two families of immunoglobulin (Ig)-like genes that are rearranged and expressed in T lymphocytes. The genes coding for the alpha subunit of T-cell receptors are on chromosome 14 and the gamma genes, whose function is yet to be determined, are on chromosome 13. Since genes for the T-cell receptor beta chain were previously shown to be on mouse chromosome 6, all three of the Ig-like multigene families expressed and rearranged in T cells are located on different chromosomes, just as are the B-cell multigene families for the Ig heavy chain, and the Ig kappa and lambda light chains. The findings do not support earlier contentions that genes for T-cell receptors are linked to the Ig heavy chain locus (mouse chromosome 12) or to the major histocompatibility complex (mouse chromosome 17).
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F H Ruddle, and
H N Eisen, and
S Tonegawa
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H Saito, and
C M Disteche, and
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D Pravtcheva, and
F H Ruddle, and
H N Eisen, and
S Tonegawa
April 1988,
Journal of immunology (Baltimore, Md. : 1950),
D M Kranz, and
H Saito, and
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K Swisshelm, and
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F H Ruddle, and
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S Tonegawa
January 1987,
Immunogenetics,
D M Kranz, and
H Saito, and
C M Disteche, and
K Swisshelm, and
D Pravtcheva, and
F H Ruddle, and
H N Eisen, and
S Tonegawa
December 1994,
European journal of immunology,
D M Kranz, and
H Saito, and
C M Disteche, and
K Swisshelm, and
D Pravtcheva, and
F H Ruddle, and
H N Eisen, and
S Tonegawa
January 1988,
Immunological reviews,
D M Kranz, and
H Saito, and
C M Disteche, and
K Swisshelm, and
D Pravtcheva, and
F H Ruddle, and
H N Eisen, and
S Tonegawa
April 1992,
Arerugi = [Allergy],
D M Kranz, and
H Saito, and
C M Disteche, and
K Swisshelm, and
D Pravtcheva, and
F H Ruddle, and
H N Eisen, and
S Tonegawa
June 1988,
European journal of immunology,
D M Kranz, and
H Saito, and
C M Disteche, and
K Swisshelm, and
D Pravtcheva, and
F H Ruddle, and
H N Eisen, and
S Tonegawa
October 1996,
Neurology,
D M Kranz, and
H Saito, and
C M Disteche, and
K Swisshelm, and
D Pravtcheva, and
F H Ruddle, and
H N Eisen, and
S Tonegawa
June 1986,
Molecular biology & medicine,
D M Kranz, and
H Saito, and
C M Disteche, and
K Swisshelm, and
D Pravtcheva, and
F H Ruddle, and
H N Eisen, and
S Tonegawa
January 1988,
Experimental cell biology,
