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Two siblings with eosinophilic gastroenteritis who presented with severe iron deficiency anemia and hypoalbuminemia associated with varying degrees of mucosal damage are described. Using a monoclonal antibody to the secreted form of eosinophil cationic protein, we demonstrated activated degranulating eosinophils in the gastrointestinal mucosa that correlated with the degree of histologic damage. This finding suggests that eosinophils may have a primary role in the tissue damage in this condition. Oral disodium cromoglycate (Nalcrom) failed to alter the clinical, radiologic, and histologic abnormalities. Prednisolone, however, was beneficial in 1 case but did not completely reverse the abnormalities.
A Keshavarzian, and
S H Saverymuttu, and
P C Tai, and
M Thompson, and
S Barter, and
C J Spry, and
V S Chadwick
January 2022,
Frontiers in immunology,
A Keshavarzian, and
S H Saverymuttu, and
P C Tai, and
M Thompson, and
S Barter, and
C J Spry, and
V S Chadwick
January 1998,
Medecine tropicale : revue du Corps de sante colonial,
A Keshavarzian, and
S H Saverymuttu, and
P C Tai, and
M Thompson, and
S Barter, and
C J Spry, and
V S Chadwick
October 1975,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
A Keshavarzian, and
S H Saverymuttu, and
P C Tai, and
M Thompson, and
S Barter, and
C J Spry, and
V S Chadwick
January 2000,
Journal of pediatric gastroenterology and nutrition,
A Keshavarzian, and
S H Saverymuttu, and
P C Tai, and
M Thompson, and
S Barter, and
C J Spry, and
V S Chadwick
September 1975,
Revista espanola de las enfermedades del aparato digestivo,
A Keshavarzian, and
S H Saverymuttu, and
P C Tai, and
M Thompson, and
S Barter, and
C J Spry, and
V S Chadwick
August 1993,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
A Keshavarzian, and
S H Saverymuttu, and
P C Tai, and
M Thompson, and
S Barter, and
C J Spry, and
V S Chadwick
January 1981,
Duodecim; laaketieteellinen aikakauskirja,
A Keshavarzian, and
S H Saverymuttu, and
P C Tai, and
M Thompson, and
S Barter, and
C J Spry, and
V S Chadwick
April 1976,
Southern medical journal,
A Keshavarzian, and
S H Saverymuttu, and
P C Tai, and
M Thompson, and
S Barter, and
C J Spry, and
V S Chadwick
June 2008,
Gastroenterology clinics of North America,
A Keshavarzian, and
S H Saverymuttu, and
P C Tai, and
M Thompson, and
S Barter, and
C J Spry, and
V S Chadwick
May 1989,
Harefuah,
