-transparent.png){kind=logo}
In synaptosomal fractions of rat brain the activities of phospholipase A2 and the phospholipid base-exchange enzymes are highly dependent on external Ca2+ concentrations. Their activity is inhibited by the presence of 50 mM ethanol in vitro. Administration of ethanol to rats by inhalation causes a progressive increase in the activity of these enzymes in synaptosomal preparations at all Ca2+ concentrations studied. The increased activity of these enzymes persists in preparations from rats undergoing a physical syndrome of withdrawal from ethanol. The addition of ethanol in vitro to preparations from animals that had received ethanol in vivo had no significant effect on enzyme activity. The results are discussed in relation to the possible roles of membrane lipid metabolism and synaptic Ca2+ sensitivity in ethanol tolerance and physical dependence.
G R John, and
J M Littleton, and
P T Nhamburo
January 1983,
Pharmacology, biochemistry, and behavior,
G R John, and
J M Littleton, and
P T Nhamburo
January 1983,
Psychopharmacology,
G R John, and
J M Littleton, and
P T Nhamburo
October 1994,
Neurochemistry international,
G R John, and
J M Littleton, and
P T Nhamburo
August 1983,
Neurochemical research,
G R John, and
J M Littleton, and
P T Nhamburo
October 2004,
Biochimica et biophysica acta,
G R John, and
J M Littleton, and
P T Nhamburo
May 1983,
Archives of biochemistry and biophysics,
G R John, and
J M Littleton, and
P T Nhamburo
July 1977,
Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles,
G R John, and
J M Littleton, and
P T Nhamburo
February 1986,
Journal of neurochemistry,
G R John, and
J M Littleton, and
P T Nhamburo
March 2000,
General physiology and biophysics,
G R John, and
J M Littleton, and
P T Nhamburo
December 1992,
The Japanese journal of psychiatry and neurology,
