Biomaterial Database

Brain arachidonic acid metabolites. Functions and interactions with ethanol. 1985

J Y Westcott, and A C Collins

The formation and potential function of arachidonic acid metabolites in brain are reviewed briefly. Cyclooxygenase metabolites of arachidonic acid are formed in brain, but the lipoxygenase derivatives have not been demonstrated. Evidence clearly indicates that the cyclooxygenase products act as neuromodulators. Possible effects of leukotrienes on brain function remain in doubt, although several studies have suggested a role for the leukotrienes and it appears that these agents have a long-lasting effect. Potential interactions between ethanol and brain arachidonic acid metabolites have received minimal attention. Several studies indicate that pretreatment with prostaglandin synthetase inhibitors produces antagonism of ethanol's behavioral effects. These observations may be related to preliminary findings that ethanol increases brain prostaglandin content.

UI	MeSH Term	Description	Entries
D007213	Indomethacin	A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.	Amuno,Indocid,Indocin,Indomet 140,Indometacin,Indomethacin Hydrochloride,Metindol,Osmosin
D011453	Prostaglandins	A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.	Prostaglandin,Prostanoid,Prostanoids
D001921	Brain	The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.	Encephalon
D001923	Brain Chemistry	Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.	Chemistry, Brain,Brain Chemistries,Chemistries, Brain
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000431	Ethanol	A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.	Alcohol, Ethyl,Absolute Alcohol,Grain Alcohol,Alcohol, Absolute,Alcohol, Grain,Ethyl Alcohol
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001095	Arachidonic Acids		Eicosatetraenoic Acids,Acids, Arachidonic,Acids, Eicosatetraenoic
D001519	Behavior	The observable response of a man or animal to a situation.	Acceptance Process,Acceptance Processes,Behaviors,Process, Acceptance,Processes, Acceptance

Related Publications

J Y Westcott, and A C Collins

Biochemical interactions of ethanol with the arachidonic acid cascade.

January 1985, Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism,

J Y Westcott, and A C Collins

Ischemia stress and arachidonic acid metabolites in the fetal brain.

January 1989, Annals of the New York Academy of Sciences,

J Y Westcott, and A C Collins

[Arachidonic acid metabolites and shock].

April 1985, Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete,

J Y Westcott, and A C Collins

Metabolites of arachidonic acid.

January 1984, Bibliotheca cardiologica,

J Y Westcott, and A C Collins

Metabolites of arachidonic acid.

September 1983, Clinical reviews in allergy,