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12 patients with severe chronic idiopathic thrombocytopenic purpura (ITP) were treated with i.v. polyvalent intact immunoglobulin (0.14-0.4 g/kg body weight for 5 d) because of various bleeding episodes or prior to surgery. In 9 patients a significant rise in platelet counts was noted, starting on d 2 and reaching its maximum between d 4 and 11. Thereafter, platelet counts decreased slowly, approaching pre-treatment values after 20 d in most cases. Response to immunoglobulin was reproducible, when infusions were repeated. Response to high-dose immunoglobulin was independent of age of patients and duration of disease. Platelet-associated IgG decreased in all patients tested. A pepsin-treated immunoglobulin preparation was ineffective in 3 patients.
C Korninger, and
S Panzer, and
W Graninger, and
E Neumann, and
H Niessner, and
K Lechner, and
E Deutsch
August 1981,
Lancet (London, England),
C Korninger, and
S Panzer, and
W Graninger, and
E Neumann, and
H Niessner, and
K Lechner, and
E Deutsch
August 1983,
Blood,
C Korninger, and
S Panzer, and
W Graninger, and
E Neumann, and
H Niessner, and
K Lechner, and
E Deutsch
June 1981,
Lancet (London, England),
C Korninger, and
S Panzer, and
W Graninger, and
E Neumann, and
H Niessner, and
K Lechner, and
E Deutsch
January 1985,
Haematologica,
C Korninger, and
S Panzer, and
W Graninger, and
E Neumann, and
H Niessner, and
K Lechner, and
E Deutsch
October 1985,
Nihon Sanka Fujinka Gakkai zasshi,
C Korninger, and
S Panzer, and
W Graninger, and
E Neumann, and
H Niessner, and
K Lechner, and
E Deutsch
June 1983,
Ugeskrift for laeger,
C Korninger, and
S Panzer, and
W Graninger, and
E Neumann, and
H Niessner, and
K Lechner, and
E Deutsch
January 1983,
Acta haematologica,
C Korninger, and
S Panzer, and
W Graninger, and
E Neumann, and
H Niessner, and
K Lechner, and
E Deutsch
February 1984,
Australian and New Zealand journal of medicine,
C Korninger, and
S Panzer, and
W Graninger, and
E Neumann, and
H Niessner, and
K Lechner, and
E Deutsch
January 1986,
Acta haematologica,
C Korninger, and
S Panzer, and
W Graninger, and
E Neumann, and
H Niessner, and
K Lechner, and
E Deutsch
December 1984,
British journal of haematology,
