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A study of acetaminophen (AAP) for possible carcinogenicity was conducted by administering the test chemical in pelleted diets to F344/DuCrj rats of each sex. Groups of 50 rats were administered AAP at one of two doses, either 0.45 or 0.9% for males and 0.65 or 1.3% for females. The rats were treated for 104 weeks, and then observed for 26 weeks. Control groups of 50 rats were fed basal diet throughout the study. Mean intakes of AAP by low- and high-dose rats were 195.4 and 402.1 in the males, and 335.7 and 688.0 mg/kg/day in the females, respectively. The survival rates at week 104 of each group were 86 to 90% in the males and 80 to 82% in the females. No pathologic or statistical evidence of induction of tumors by AAP was found. It is concluded that, under the conditions of this study, acetaminophen is not carcinogenic to F344/DuCrj rats of either sex.
K Hiraga, and
T Fujii
February 1983,
Journal of the National Cancer Institute,
K Hiraga, and
T Fujii
December 1990,
Japanese journal of cancer research : Gann,
K Hiraga, and
T Fujii
January 1997,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
K Hiraga, and
T Fujii
January 1986,
Journal of toxicology and environmental health,
K Hiraga, and
T Fujii
May 1997,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
K Hiraga, and
T Fujii
December 1986,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
K Hiraga, and
T Fujii
January 1992,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
K Hiraga, and
T Fujii
January 1997,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
K Hiraga, and
T Fujii
October 1992,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
K Hiraga, and
T Fujii
April 1989,
Japanese journal of cancer research : Gann,
