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MT-141, a new cephamycin (7 alpha-methoxy-cephalosporin) antibiotic with a D-cysteine moiety in its 7 beta-side chain, has binding affinities to penicillin-binding proteins of Escherichia coli and an inhibitory action on their transpeptidase activity similar to those of other structurally related cephamycins. Yet this antibiotic was found to exert an exceedingly strong and rapid lytic action on sensitive Gram-negative bacteria such as E. coli, Klebsiella pneumoniae, Serratia marcescens and Salmonella enteritidis. Not only rapidly growing cells, but also slowly growing dense cells of the above bacteria could be lysed by this antibiotic at low concentrations. In the presence of 20% sucrose, low concentrations of MT-141 induced smooth-surfaced single and twin bulges of the putative growth zone of the cells and irregularly orientated rough-surfaced bulges. Probably the 7 beta-side chain structure of this antibiotic is involved in its rapid and strong bacteriolytic action.
T Tsuruoka, and
Y Yamada, and
H Goi, and
K Miyauchi, and
A Miyata, and
S Inouye, and
F Ishino, and
A Hirata, and
M Matsuhashi
January 1985,
Drugs under experimental and clinical research,
T Tsuruoka, and
Y Yamada, and
H Goi, and
K Miyauchi, and
A Miyata, and
S Inouye, and
F Ishino, and
A Hirata, and
M Matsuhashi
May 1984,
The Japanese journal of antibiotics,
T Tsuruoka, and
Y Yamada, and
H Goi, and
K Miyauchi, and
A Miyata, and
S Inouye, and
F Ishino, and
A Hirata, and
M Matsuhashi
July 1984,
The Japanese journal of antibiotics,
T Tsuruoka, and
Y Yamada, and
H Goi, and
K Miyauchi, and
A Miyata, and
S Inouye, and
F Ishino, and
A Hirata, and
M Matsuhashi
December 1984,
The Journal of antibiotics,
T Tsuruoka, and
Y Yamada, and
H Goi, and
K Miyauchi, and
A Miyata, and
S Inouye, and
F Ishino, and
A Hirata, and
M Matsuhashi
January 1989,
Research in microbiology,
T Tsuruoka, and
Y Yamada, and
H Goi, and
K Miyauchi, and
A Miyata, and
S Inouye, and
F Ishino, and
A Hirata, and
M Matsuhashi
November 1994,
Antimicrobial agents and chemotherapy,
T Tsuruoka, and
Y Yamada, and
H Goi, and
K Miyauchi, and
A Miyata, and
S Inouye, and
F Ishino, and
A Hirata, and
M Matsuhashi
June 1984,
The Japanese journal of antibiotics,
T Tsuruoka, and
Y Yamada, and
H Goi, and
K Miyauchi, and
A Miyata, and
S Inouye, and
F Ishino, and
A Hirata, and
M Matsuhashi
June 1984,
The Japanese journal of antibiotics,
T Tsuruoka, and
Y Yamada, and
H Goi, and
K Miyauchi, and
A Miyata, and
S Inouye, and
F Ishino, and
A Hirata, and
M Matsuhashi
June 1984,
The Japanese journal of antibiotics,
T Tsuruoka, and
Y Yamada, and
H Goi, and
K Miyauchi, and
A Miyata, and
S Inouye, and
F Ishino, and
A Hirata, and
M Matsuhashi
June 1984,
The Japanese journal of antibiotics,
