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Intranasal, intravenous and oral TRH have been compared in 9 healthy volunteers. Intranasal administration of TRH leads to excellent stimulation of pituitary TSH secretion. Serum TSH levels are significantly higher than after intravenous TRH (p less than 0.005) and lower than after oral TRH (p less than 0.005). As with intravenous TRH, peak TSH response is reached at 20-30 minutes, but the stimulatory effect is prolonged and elevated TSH levels can be measured for up to 3 hours. Stimulation of T3 and free T4 at 3 hours is comparable in all three administration forms of TRH. The practical advantages of the intranasal route are that no intravenous injection is necessary, overnight fasting is not required and the duration of the test is short (30 minutes, in contrast to 3 hours in the oral test).
A S Ryff-de-Lèche, and
J J Staub, and
S Paul, and
B Polc, and
J Girard
August 1971,
Rinsho byori. The Japanese journal of clinical pathology,
A S Ryff-de-Lèche, and
J J Staub, and
S Paul, and
B Polc, and
J Girard
January 1971,
Annales d'endocrinologie,
A S Ryff-de-Lèche, and
J J Staub, and
S Paul, and
B Polc, and
J Girard
January 1973,
Revista iberica de endocrinologia,
A S Ryff-de-Lèche, and
J J Staub, and
S Paul, and
B Polc, and
J Girard
January 1978,
Endokrynologia Polska,
A S Ryff-de-Lèche, and
J J Staub, and
S Paul, and
B Polc, and
J Girard
July 1985,
Orvosi hetilap,
A S Ryff-de-Lèche, and
J J Staub, and
S Paul, and
B Polc, and
J Girard
December 1979,
Schweizerische medizinische Wochenschrift,
A S Ryff-de-Lèche, and
J J Staub, and
S Paul, and
B Polc, and
J Girard
December 1973,
L'union medicale du Canada,
A S Ryff-de-Lèche, and
J J Staub, and
S Paul, and
B Polc, and
J Girard
December 1973,
L'union medicale du Canada,
A S Ryff-de-Lèche, and
J J Staub, and
S Paul, and
B Polc, and
J Girard
August 1984,
The Journal of clinical psychiatry,
A S Ryff-de-Lèche, and
J J Staub, and
S Paul, and
B Polc, and
J Girard
January 1975,
La Prensa medica mexicana,
