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To investigate the effects of nitroglycerin on collateral blood flow 10 open chest dogs underwent coronary occlusion followed by nitroglycerin infusion (80 to 300 micrograms . min-1) to lower mean systemic blood pressure by 20 mmHg, followed by phenylephrine infusion (10 to 40 micrograms . min-1) to restore blood pressure to the pre-nitroglycerin level. Myocardial blood flow was measured with microspheres. The contribution of overlapping normal zone tissue in the ischaemic zone was evaluated with the balloon perfusion technique. Collateral flow was measured with microspheres in the most ischaemic tissue. In addition "load line" analysis was used to calculate collateral flow from retrograde flow. Nitroglycerin lowered blood flow to non-ischaemic tissue, and tended to lower blood flow to ischaemic tissue. Phenylephrine restored blood flow to the value after coronary occlusion. Load line analysis data was similar to data on myocardial blood flow from the microspheres. Collateral resistance changed little during the experiment. Th effects of nitroglycerin on collateral blood flow are, thus, minimal. While it is possible that under special circumstances there may be some decrease in collateral resistance, the bulk of data from this study and others do not support the idea that systemic infusion of nitroglycerin in the setting of an acute myocardial infarction will affect collateral flow.
W S Weintraub, and
S Cluley, and
F Naccarella, and
S Akizuki, and
J B Agarwal, and
M M Bodenheimer, and
V S Banka, and
R H Helfant
February 1984,
Journal of the American College of Cardiology,
W S Weintraub, and
S Cluley, and
F Naccarella, and
S Akizuki, and
J B Agarwal, and
M M Bodenheimer, and
V S Banka, and
R H Helfant
January 1981,
Circulation,
W S Weintraub, and
S Cluley, and
F Naccarella, and
S Akizuki, and
J B Agarwal, and
M M Bodenheimer, and
V S Banka, and
R H Helfant
January 1973,
Surgical forum,
W S Weintraub, and
S Cluley, and
F Naccarella, and
S Akizuki, and
J B Agarwal, and
M M Bodenheimer, and
V S Banka, and
R H Helfant
November 1984,
The American journal of cardiology,
W S Weintraub, and
S Cluley, and
F Naccarella, and
S Akizuki, and
J B Agarwal, and
M M Bodenheimer, and
V S Banka, and
R H Helfant
June 1983,
Circulation,
W S Weintraub, and
S Cluley, and
F Naccarella, and
S Akizuki, and
J B Agarwal, and
M M Bodenheimer, and
V S Banka, and
R H Helfant
January 1969,
Farmakologiia i toksikologiia,
W S Weintraub, and
S Cluley, and
F Naccarella, and
S Akizuki, and
J B Agarwal, and
M M Bodenheimer, and
V S Banka, and
R H Helfant
April 1974,
British heart journal,
W S Weintraub, and
S Cluley, and
F Naccarella, and
S Akizuki, and
J B Agarwal, and
M M Bodenheimer, and
V S Banka, and
R H Helfant
January 1973,
Recent advances in studies on cardiac structure and metabolism,
W S Weintraub, and
S Cluley, and
F Naccarella, and
S Akizuki, and
J B Agarwal, and
M M Bodenheimer, and
V S Banka, and
R H Helfant
June 1975,
The Journal of clinical investigation,
W S Weintraub, and
S Cluley, and
F Naccarella, and
S Akizuki, and
J B Agarwal, and
M M Bodenheimer, and
V S Banka, and
R H Helfant
August 1978,
Cardiovascular research,
