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When complementary fragments of the imaginal wing disc of Drosophila are cultured for several days prior to inducing metamorphosis, usually one fragment will regenerate while the second duplicates. It has been proposed that wound healing plays an important part in disc regulation by initiating cell proliferation and determining the mode of regulation (regeneration/duplication). To test the latter proposal 15 types of wing disc fragments were examined for variability both in the mode of wound healing and the mode of pattern regulation. Two modes of wound healing were observed, regular - the two wound edges heal with each other, and irregular - each wound edge heals with itself. When cultured separately fragments that healed regularly regenerated, while fragments that healed irregularly duplicated. This suggests that the mode of wound healing determines the mode of pattern regulation.
L Dale, and
M Bownes
April 1981,
The Journal of experimental zoology,
L Dale, and
M Bownes
October 1977,
Developmental biology,
L Dale, and
M Bownes
April 2005,
Developmental biology,
L Dale, and
M Bownes
April 1985,
Developmental biology,
L Dale, and
M Bownes
November 1984,
Developmental biology,
L Dale, and
M Bownes
April 2003,
Development (Cambridge, England),
L Dale, and
M Bownes
January 2014,
PloS one,
L Dale, and
M Bownes
September 2019,
Development (Cambridge, England),
L Dale, and
M Bownes
September 2010,
BMC developmental biology,
L Dale, and
M Bownes
July 1987,
Brain research,
