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Because of some indication that FSH secretion is less dependent than LH secretion on GnRH in vivo, we performed experiments to examine the effects of a GnRH antagonist (antag) on LH and FSH secretion. We first showed that pituitary cells superfused with GnRH showed a similar pattern of suppressed secretion of both LH and FSH in response to addition of antag. In contrast, antag administration to ovariectomized rats had differing effects on LH and FSH secretion. Serum LH was suppressed in a dose-dependent fashion by 2 h (20-50% of control values). Recovery from the lower doses of antag was seen by 12 h, but the two highest doses maintained serum LH levels at 10% of control values for 72 h. In contrast, the effect on serum FSH was not manifested until 12 h. FSH was maximally decreased only to 40-60% of control values. The two highest doses maintained this effect for 72 h. These results reinforce previous suggestions that FSH secretion in vivo may occur independently of acute changes in GnRH secretion, and may have an GnRH-independent component.
R R Grady, and
L Shin, and
M C Charlesworth, and
I R Cohen-Becker, and
M Smith, and
C Rivier, and
J Rivier, and
W Vale, and
N B Schwartz
January 2001,
Archives of medical research,
R R Grady, and
L Shin, and
M C Charlesworth, and
I R Cohen-Becker, and
M Smith, and
C Rivier, and
J Rivier, and
W Vale, and
N B Schwartz
June 1989,
Fertility and sterility,
R R Grady, and
L Shin, and
M C Charlesworth, and
I R Cohen-Becker, and
M Smith, and
C Rivier, and
J Rivier, and
W Vale, and
N B Schwartz
April 1987,
The Journal of clinical endocrinology and metabolism,
R R Grady, and
L Shin, and
M C Charlesworth, and
I R Cohen-Becker, and
M Smith, and
C Rivier, and
J Rivier, and
W Vale, and
N B Schwartz
September 1971,
Science (New York, N.Y.),
R R Grady, and
L Shin, and
M C Charlesworth, and
I R Cohen-Becker, and
M Smith, and
C Rivier, and
J Rivier, and
W Vale, and
N B Schwartz
July 1996,
Biology of reproduction,
R R Grady, and
L Shin, and
M C Charlesworth, and
I R Cohen-Becker, and
M Smith, and
C Rivier, and
J Rivier, and
W Vale, and
N B Schwartz
September 1986,
Biology of reproduction,
R R Grady, and
L Shin, and
M C Charlesworth, and
I R Cohen-Becker, and
M Smith, and
C Rivier, and
J Rivier, and
W Vale, and
N B Schwartz
March 1985,
Biology of reproduction,
R R Grady, and
L Shin, and
M C Charlesworth, and
I R Cohen-Becker, and
M Smith, and
C Rivier, and
J Rivier, and
W Vale, and
N B Schwartz
June 1986,
Fertility and sterility,
R R Grady, and
L Shin, and
M C Charlesworth, and
I R Cohen-Becker, and
M Smith, and
C Rivier, and
J Rivier, and
W Vale, and
N B Schwartz
January 1979,
The Journal of endocrinology,
R R Grady, and
L Shin, and
M C Charlesworth, and
I R Cohen-Becker, and
M Smith, and
C Rivier, and
J Rivier, and
W Vale, and
N B Schwartz
March 1995,
European journal of endocrinology,
