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The effect of cerebral intraventricular administration of 6-hydroxydopamine (6-OHDA) on blood pressure and vascular smooth muscle responsiveness in deoxycorticosterone acetate (DOCA)-treated rats was assessed. Rats treated with 6-OHDA and DOCA had significantly lower systolic blood pressures (142 +/- 8 mm Hg) than rats treated with DOCA alone (185 +/- 5 mm Hg). After 5 weeks of DOCA treatment, femoral arteries and aortae were excised from these rats, cut helically into strips, and placed in a muscle bath to record isometric force. Dose-response curves to serotonin were shifted to the left in femoral arteries from DOCA-treated rats compared to both control and 6-OHDA-DOCA-treated rats (ED50: DOCA = 6.8 X 10(-8) M, control = 27.9 X 10(-8) M, 6-OHDA-DOCA = 13.4 X 10(-8) M). Arachidonic acid, the prostaglandin precursor, produced greater maximal contractions in femoral artery strips of DOCA-treated rats (358 +/- 56 mg) than in those from controls (115 +/- 31 mg). The maximal response to arachidonic acid in arteries from 6-OHDA-DOCA rats (203 +/- 78 mg) was not different from control values. Ouabain produced a greater maximal response in aortic strips from DOCA rats (658 +/- 165 mg) compared to those from control (196 +/- 72 mg) or 6-OHDA-DOCA (309 +/- 87 mg) rats. We conclude that increased vascular responsiveness to serotonin, arachidonic acid, and ouabain in DOCA hypertensive rats is secondary to a central action of the mineralocorticoid.
T E Mecca, and
F S Lamb, and
J L Hall, and
R C Webb
August 1976,
Research communications in chemical pathology and pharmacology,
T E Mecca, and
F S Lamb, and
J L Hall, and
R C Webb
August 1986,
Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova,
T E Mecca, and
F S Lamb, and
J L Hall, and
R C Webb
April 1972,
Nature: New biology,
T E Mecca, and
F S Lamb, and
J L Hall, and
R C Webb
January 1956,
Arkhiv patologii,
T E Mecca, and
F S Lamb, and
J L Hall, and
R C Webb
January 1980,
Anatomy and embryology,
T E Mecca, and
F S Lamb, and
J L Hall, and
R C Webb
November 1970,
British journal of pharmacology,
T E Mecca, and
F S Lamb, and
J L Hall, and
R C Webb
May 1974,
Pharmacology, biochemistry, and behavior,
T E Mecca, and
F S Lamb, and
J L Hall, and
R C Webb
August 1978,
Archives internationales de pharmacodynamie et de therapie,
T E Mecca, and
F S Lamb, and
J L Hall, and
R C Webb
March 1978,
Archives internationales de pharmacodynamie et de therapie,
T E Mecca, and
F S Lamb, and
J L Hall, and
R C Webb
July 1978,
Research communications in chemical pathology and pharmacology,
