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One-third of Wistar rats bred in our laboratory present recurrent seizures whose EEG and clinical symptomatology resemble those of human petit mal. Bilateral cortical synchronous spike- and wave discharges (7-11 c/s; 200-600 microV, lasting 0.5 to 40 s) accompany behavioral arrest and are associated frequently with facial myoclonia. These seizures, observed as long as the animals survive, appear spontaneously and seem to be unrelated to surgical procedures. Antiepileptics in common clinical use were tested. Ethosuximide (greater than 12.5 mg/kg), diazepam (greater than 0.5 mg/kg), trimethadione and sodium valproate (greater than 50 mg/kg) suppressed these discharges in a dose related manner. Carbamazepine and phenytoin were ineffective or aggravated the seizures. Phenobarbital, effective at 2.5 to 10 mg/kg, was ineffective at 20 mg/kg. The similar effects of these antiepileptics on both the rats' seizures and human petit mal confirm the hypothesis that this phenomenon constitutes a valid pharmacological model of petit mal epilepsy. Its predictive value appears to be superior to that of other currently used models.
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M Vergnes, and
C Marescaux, and
J Reis, and
A Depaulis, and
L Rumbach, and
J M Warter
October 1958,
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G Micheletti, and
M Vergnes, and
C Marescaux, and
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A Depaulis, and
L Rumbach, and
J M Warter
January 1980,
Psychopharmacology,
G Micheletti, and
M Vergnes, and
C Marescaux, and
J Reis, and
A Depaulis, and
L Rumbach, and
J M Warter
January 1987,
Laboratory animals,
G Micheletti, and
M Vergnes, and
C Marescaux, and
J Reis, and
A Depaulis, and
L Rumbach, and
J M Warter
October 1953,
Neurology,
G Micheletti, and
M Vergnes, and
C Marescaux, and
J Reis, and
A Depaulis, and
L Rumbach, and
J M Warter
September 1954,
The Journal of pediatrics,
G Micheletti, and
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A Depaulis, and
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J M Warter
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G Micheletti, and
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C Marescaux, and
J Reis, and
A Depaulis, and
L Rumbach, and
J M Warter
April 1970,
Rivista di patologia nervosa e mentale,
G Micheletti, and
M Vergnes, and
C Marescaux, and
J Reis, and
A Depaulis, and
L Rumbach, and
J M Warter
December 1962,
Pediatrics,
G Micheletti, and
M Vergnes, and
C Marescaux, and
J Reis, and
A Depaulis, and
L Rumbach, and
J M Warter
December 1958,
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G Micheletti, and
M Vergnes, and
C Marescaux, and
J Reis, and
A Depaulis, and
L Rumbach, and
J M Warter
January 1978,
American family physician,
