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Fourteen patients with Paget's disease of bone were treated with disodium etidronate in doses of 5 to 7 mg/kg per day. Skeletal blood flow (SBF), was measured by the modified 18F clearance technique of Wootton et al. (1976) before treatment and again during treatment. In 10 patients restudied 3-4 months after the start of therapy, SBF had fallen by a mean of 21% of the initial value, and the individual differences correlated well with the individual reductions in serum alkaline phosphatase (r = 0.77, P less than 0.01). The results were similar to those seen in an earlier study in patients treated with calcitonin. However, no early reduction in SBF was seen in six repeat studies performed at the end of the second week of treatment, in contrast with our previous findings with calcitonin.
K R Walton, and
J R Green, and
J Reeve, and
R Wootton
September 1978,
The Medical letter on drugs and therapeutics,
K R Walton, and
J R Green, and
J Reeve, and
R Wootton
May 1984,
Archives of internal medicine,
K R Walton, and
J R Green, and
J Reeve, and
R Wootton
January 1998,
The Kurume medical journal,
K R Walton, and
J R Green, and
J Reeve, and
R Wootton
October 1987,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
K R Walton, and
J R Green, and
J Reeve, and
R Wootton
May 1982,
Annals of internal medicine,
K R Walton, and
J R Green, and
J Reeve, and
R Wootton
November 1985,
The American journal of medicine,
K R Walton, and
J R Green, and
J Reeve, and
R Wootton
April 1973,
The Quarterly journal of medicine,
K R Walton, and
J R Green, and
J Reeve, and
R Wootton
January 1987,
Bone,
K R Walton, and
J R Green, and
J Reeve, and
R Wootton
January 1984,
Revue du rhumatisme et des maladies osteo-articulaires,
K R Walton, and
J R Green, and
J Reeve, and
R Wootton
January 1982,
Medicina,
