-transparent.png){kind=logo}
The failure of clinical trials to demonstrate any anti-anginal properties of the transdermal nitroglycerin units has resulted in the re-evaluation of one such product, Transiderm-Nitro. Haemodynamic assessment following the application of 10, 20 and 40 cm2 units has been made in eight healthy volunteers over a 6 h period. Measurements of heart rate, blood pressure, stroke volume and left ventricular dimension (by 'M' mode echocardiography) were made 2 h after the application of the units. End diastolic dimension fell by 5.2% and stress by 12.6% implying a reduction in myocardial oxygen consumption. However this was offset by an increase in double product of 10.7% and in circumferential fibre shortening of 23.4%. These results imply that the doses used produce venodilatation leading to a reduction in myocardial oxygen consumption. However this is counterbalanced by the reflex induced increase in heart rate and inotropic state. It suggests therefore that much larger doses are required to produce significant anti-anginal effects.
E D Bennett, and
A L Davis
July 1983,
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,
E D Bennett, and
A L Davis
February 1995,
Circulation,
E D Bennett, and
A L Davis
January 1991,
Journal of clinical epidemiology,
E D Bennett, and
A L Davis
January 2001,
Pediatric cardiology,
E D Bennett, and
A L Davis
February 1993,
Journal of the American College of Cardiology,
E D Bennett, and
A L Davis
August 1984,
Deutsche medizinische Wochenschrift (1946),
E D Bennett, and
A L Davis
October 1969,
Cuore e circolazione,
E D Bennett, and
A L Davis
February 2011,
Current atherosclerosis reports,
E D Bennett, and
A L Davis
January 1972,
Bollettino della Societa italiana di cardiologia,
E D Bennett, and
A L Davis
November 1974,
L'union medicale du Canada,
